Sceptrin . dihydrochloride [79703-25-6]

Catalog number: AG-CN2-0440-C500
Brand: AdipoGen Life Sciences
Packing: 500 ug
Price: € 85.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - Sceptrin . dihydrochloride [79703-25-6]

Product group: Chemicals
Category: Antibiotics
Source: Isolated from the sponge Agelas nakamurai.
CAS No.: 79703-25-6
Purity: >97% (HPLC)
Molecular Formula: C22H24Br2N10O2 . 2HCl
Molecular weight: 620.3 . 72.9
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Antibiotic. Inhibits the growth of several Gram-positive and Gram-negative bacteria. Binds to MreB inducing disruption of the bacterial cell wall. Competitive inhibitor of muscarinic acetylcholine receptors (mAChR). Cell motility inhibitor by specifically blocking contractility of the cell. Direct binding with monomeric actin disrupts the polymerization of actin into microfilaments necessary for cellular mechanical processes.
Safety information: 
Hazard information: H302, H319, H332, H335
Additional information: 
Synonyms: AG-CN2-0440-C500; AdipoGen Life Sciences
Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges: R. Rosa, et al.; Experientia 48, 885 (1992) Read more
A study on the mechanism of action of sceptrin, an antimicrobial agent isolated from the South Pacific sponge Agelas mauritiana: V.S. Bernan, et al.; J. Antimicrob. Chemother. 32, 539 (1993) Read more
Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol: A.D. Rodriguez, et al.; JACS 130, 7256 (2008) Read more
Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines: A. Cipres, et al.; ACS Chem. Biol. 5, 195 (2010) Read more
Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence: Z. Ma, et al.; Science 346, 219 (2014) Read more