Selumetinib (AZD6244) [606143-52-6]
S1008
Overview
- SupplierSelleck Chemicals
- Product NameSelumetinib (AZD6244) [606143-52-6]
- Delivery Days Customer9
- CAS Number606143-52-6
- CertificationResearch Use Only
- Scientific DescriptionSelumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38alfa, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.
- UNSPSC12352200