Shikonin [517-89-5]

MedChem Express

Shikonin [517-89-5]

10

517-89-5

Research Use Only

98.09%

C16H16O5

288.3

Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 microM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-alpha and NF-kappaB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.

O=C1C([C@H](O)C/C=C(C)/C)=CC(C2=C1C(O)=CC=C2O)=O

2°C to 8°C,-20°C,-80°C

12352200