Shikonin [517-89-5]
HY-N0822
Overview
- SupplierMedChem Express
- Product NameShikonin [517-89-5]
- Delivery Days Customer10
- CAS Number517-89-5
- CertificationResearch Use Only
- Estimated Purity98.09%
- Molecular FormulaC16H16O5
- Molecular Weight288.3
- Scientific DescriptionShikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 microM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-alpha and NF-kappaB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
- SMILESO=C1C([C@H](O)C/C=C(C)/C)=CC(C2=C1C(O)=CC=C2O)=O
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200