SHIN1 [2146095-85-2]

Catalog number: HY-112066_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: 5 mg
10 mM
10 mg
25 mg
50 mg
Price: € 3,453.30 € 3837.00
Expected delivery time: 10 days

Product specifications for - SHIN1 [2146095-85-2]

Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 2146095-85-2
Molecular Formula: C24H24N4O2
Molecular weight: 400.47
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. IC50 & Target: IC50: 5 nM (SHMT1), 13 nM (SHMT1) In Vitro: SHIN1 inhibits human SHIN1 SHMT1/2 with IC50s of 5 and 13 nM, respectively in an in vitro assay. SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells with an IC50 of 10 nM. SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 is particularly active against B-cell malignancies. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates.
Safety information: 
Additional information: 
Synonyms: HY-112066; MedChem Express