Bio-Connect
Chemical Structure
Chemical Structure
Chemical Structure

Sibiriline [1346526-26-8]

Research Use Only
AG-CR1-0160
AdipoGen Life Sciences
CAS Number1346526-26-8
Product group Chemicals
Estimated Purity>98%
Molecular Weight210.2
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Sibiriline [1346526-26-8]
  • Delivery Days Customer
    10
  • CAS Number
    1346526-26-8
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C13H10N2O
  • Molecular Weight
    210.2
  • Scientific Description
    Chemical. CAS: 1346526-26-8. Formula: C13H10N2O. MW: 210.2. Specific competitive RIPK1 inhibitor in vitro (IC50=1.03microM). Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases. Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2microM). Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine. Protects mice from concanavalin A-induced hepatitis in vivo. - Specific competitive RIPK1 inhibitor in vitro (IC50=1.03microM). Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases. Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2microM). Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine. Protects mice from concanavalin A-induced hepatitis in vivo.
  • SMILES
    OC(C=C1)=CC=C1C2=CC3=CC=CN=C3N2
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200