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Siramesine hydrochloride [224177-60-0]

Research Use Only
HY-14221A
MedChem Express
CAS Number224177-60-0
Product group Chemicals
Estimated Purity99.05%
Molecular Weight491.04
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Siramesine hydrochloride [224177-60-0]
  • Delivery Days Customer
    10
  • CAS Number
    224177-60-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.05%
  • Molecular Formula
    C30H32ClFN2O
  • Molecular Weight
    491.04
  • Scientific Description
    Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.
  • SMILES
    FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=C4C=CC=C5)C6=C2C=CC=C6)C=C1.Cl
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200