Sirtinol [410536-97-9]

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Chemical Structure

Chemical Structure...

Product specifications for - Sirtinol [410536-97-9]

Overview:
Product group:	Chemicals
Category:	Other
CAS No.:	410536-97-9

Properties:
Purity:	>98% (NMR)
Molecular Formula:	C26H22N2O2
Molecular weight:	394.5
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352200
Storage instructions:	2-¦C to 8-¦C

Scientific information:
Scientific info:	Chemical. CAS: 410536-97-9. Formula: C26H22N2O2. MW: 394.5. Specific cell permeable SIRT1 (sirtuin 1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer. - Specific cell permeable SIRT1 (sirtuin 1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer.

Safety information:
MSDS:	MSDS
Hazard information:	Non-hazardous

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001)

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005)

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006)

A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase: F.C. Liu, et al.; Biochem. Pharmacol. 77, 1364 (2009)

SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2: B. Peck, et al.; Mol. Cancer Ther. 9, 844 (2010)

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Product specifications for - Sirtinol [410536-97-9]