Sirtinol [410536-97-9]

Catalog number: AG-CR1-0055-M025
Brand: AdipoGen Life Sciences
Packing: 25 mg
Other sizes: Other sizes available
Price: € 165.00
Expected delivery time: 7 days
Quantity:
Chemical Structure
Chemical Structure...

Product specifications for - Sirtinol [410536-97-9]

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 410536-97-9
Properties: 
Purity: >98% (NMR)
Molecular Formula: C26H22N2O2
Molecular weight: 394.5
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: 2-¦C to 8-¦C
Scientific information: 
Scientific info: Chemical. CAS: 410536-97-9. Formula: C26H22N2O2. MW: 394.5. Specific cell permeable SIRT1 (sirtuin 1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer. - Specific cell permeable SIRT1 (sirtuin 1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer.
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001) Read more
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005) Read more
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006) Read more
A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase: F.C. Liu, et al.; Biochem. Pharmacol. 77, 1364 (2009) Read more
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2: B. Peck, et al.; Mol. Cancer Ther. 9, 844 (2010) Read more