Sirtinol [410536-97-9]

Name: Sirtinol [410536-97-9]
SKU: AG-CR1-0055_A27
Price: 36 EUR
Availability: InStock

AG-CR1-0055

CAS Number410536-97-9

Product group Chemicals

Estimated Purity>98% (NMR)

Molecular Weight394.5

Overview

Supplier
AdipoGen Life Sciences
Product Name
Sirtinol [410536-97-9]
Delivery Days Customer
10
CAS Number
410536-97-9
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous
Molecular Formula
C26H22N2O2
Molecular Weight
394.5
Scientific Description
Chemical. CAS: 410536-97-9. Formula: C26H22N2O2. MW: 394.5. Specific cell permeable SIRT1 (sirtuin 1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer. - Specific cell permeable SIRT1 (sirtuin 1) inhibitor [1, 2]. Senescence-like growth arrest inducer [3]. Platelet aggregation inhibitor [4]. Apoptosis inducer [5].
SMILES
CC(NC(=O)C1=C(C=CC=C1)\N=C\C1=C(O)C=CC2=C1C=CC=C2)C1=CC=CC=C1
Storage Instruction
2°C to 8°C
UNSPSC
12352200

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001)
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005)
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006)
A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase: F.C. Liu, et al.; Biochem. Pharmacol. 77, 1364 (2009)
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2: B. Peck, et al.; Mol. Cancer Ther. 9, 844 (2010)