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Sitravatinib [1123837-84-2]

Research Use Only
HY-16961
MedChem Express
CAS Number1123837-84-2
Product group Chemicals
Estimated Purity98.2%
Molecular Weight629.68
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Sitravatinib [1123837-84-2]
  • Delivery Days Customer
    10
  • CAS Number
    1123837-84-2
  • Certification
    Research Use Only
  • Estimated Purity
    98.2%
  • Molecular Formula
    C33H29F2N5O4S
  • Molecular Weight
    629.68
  • Scientific Description
    Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.
  • SMILES
    O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=C5C(C=C(C6=NC=C(CNCCOC)C=C6)S5)=NC=C4)C(F)=C3
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200