Sorafenib (BAY 43-9006) [284461-73-0]
S7397
Overview
- SupplierSelleck Chemicals
- Product NameSorafenib (BAY 43-9006) [284461-73-0]
- Delivery Days Customer9
- CAS Number284461-73-0
- CertificationResearch Use Only
- Scientific DescriptionSorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-bèta, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
- UNSPSC12352200