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(S,R,S)-AHPC hydrochloride [1448189-80-7]

HY-101763A
MedChem Express
CAS Number1448189-80-7
Product group Chemicals
Estimated Purity95.05%
Molecular Weight467.02
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (S,R,S)-AHPC hydrochloride [1448189-80-7]
  • Delivery Days Customer
    10
  • CAS Number
    1448189-80-7
  • Estimated Purity
    95.05%
  • Molecular Formula
    C22H31ClN4O3S
  • Molecular Weight
    467.02
  • Scientific Description
    (S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 microM in Ba/F3 cells.
  • SMILES
    O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
  • Storage Instruction
    -20°C,-80°C
  • UNSPSC
    12352200