(S,R,S)-AHPC hydrochloride [1448189-80-7]
HY-101763A
CAS Number1448189-80-7
Product group Chemicals
Estimated Purity95.05%
Molecular Weight467.02
Overview
- SupplierMedChem Express
- Product Name(S,R,S)-AHPC hydrochloride [1448189-80-7]
- Delivery Days Customer10
- CAS Number1448189-80-7
- Estimated Purity95.05%
- Molecular FormulaC22H31ClN4O3S
- Molecular Weight467.02
- Scientific Description(S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 microM in Ba/F3 cells.
- SMILESO=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
- Storage Instruction-20°C,-80°C
- UNSPSC12352200