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Chemical Structure
Chemical Structure
Chemical Structure

STF-31 [724741-75-7]

Research Use Only
AG-CR1-3693
AdipoGen Life Sciences
CAS Number724741-75-7
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Product group Chemicals
Estimated Purity>98%
Molecular Weight423.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    STF-31 [724741-75-7]
  • Delivery Days Customer
    10
  • CAS Number
    724741-75-7
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C23H25N3O3S
  • Molecular Weight
    423.5
  • Scientific Description
    Chemical. CAS: 724741-75-7. Formula: C23H25N3O3S. MW: 423.5. . Specific nicotinamide phosphoribosyltransferase (NAMPT) inhibitor (IC50 = 19nM), consequently blocking the NAD+ salvage pathway and leading to blockage of GLUT1 expression. Glucose transporter 1 (GLUT1) inhibitor (IC50 ~1microM). Inhibits glucose uptake across the plasma membranes of mammalian cells and consequently decreases glycolysis. Anticancer agent. Shown to induce necrosis in cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor gene, which overexpress GLUT1. VHL-deficient cancer cells are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. Completely suppressed the glucose uptake activity and induced apoptosis in GLUT1 expressing myeloma cells as well. Useful agent for immunometabolism research. Toxic to human pluripotent stem cells (hPSCs) and used to selectively eliminate hPSCs from mixed cultures. - Specific nicotinamide phosphoribosyltransferase (NAMPT) inhibitor (IC50=19nM), consequently blocking the NAD+ salvage pathway and leading to blockage of GLUT1 expression. Glucose transporter 1 (GLUT1) inhibitor (IC50 ~1microM). Inhibits glucose uptake across the plasma membranes of mammalian cells and consequently decreases glycolysis. Anticancer agent. Shown to induce necrosis in cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor gene, which overexpresses GLUT1. VHL-deficient cancer cells are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. Completely suppresses the glucose uptake activity and induces apoptosis in GLUT1 expressing myeloma cells as well. Useful agent for immunometabolism research. Toxic to human pluripotent stem cells (hPSCs) and used to selectively eliminate hPSCs from mixed cultures.
  • SMILES
    O=C(NC1=CC=CN=C1)C2=CC=C(CNS(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)C=C2
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality: D.A. Chan, et al.; Sci. Transl. Med. 3, 94ra70 (2011)
  • NAMPT is the cellular target of STF-31-like small-molecule probes: D.J. Adams, et al.; ACS Chem. Biol. 9, 2247 (2014)
  • Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphribosyltransferase (NAMPT): P.S. Dragovich, et al.; Bioorg. Med. Chem. Lett. 24, 954 (2014)
  • A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets: K.R. Boheler, et al.; Stem Cell Reports 3, 185 (2014)
  • Inhibition of an NAD⁺ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells: E.M. Kropp, et al.; Stem Cells Transl. Med. 4, 483 (2015)
  • A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models: C. Xintaropoulou, et al.; Oncotarget 6, 25677 (2015) (Review)
  • Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells: A. Nomura, et al.; Oncotarget 7, 56324 (2016)
  • A guide to immunometabolism for immunologists: L.A. O'Neill, et al.; Nat. Rev. Immunol. 16, 553 (2016) (Review)
  • Inhibition of glucose transporter 1 induces apoptosis and sensitizes multiple myeloma cells to conventional chemotherapeutic agents: T. Matsumoto, et al.; Leuk. Res. 41, 103 (2016)
  • Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity: A. Pingitore, et al.; Cell Physiol. Biochem. 44, 1352 (2017)