Tacrolimus (FK506) [104987-11-3]

Selleck Chemicals

Tacrolimus (FK506) [104987-11-3]

9

104987-11-3

Research Use Only

Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.

12352200