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TAK-220 [333994-00-6]

Research Use Only
HY-19974
MedChem Express
CAS Number333994-00-6
Product group Chemicals
Estimated Purity99.9%
Molecular Weight553.14
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    TAK-220 [333994-00-6]
  • Delivery Days Customer
    10
  • CAS Number
    333994-00-6
  • Certification
    Research Use Only
  • Estimated Purity
    99.9%
  • Molecular Formula
    C31H41ClN4O3
  • Molecular Weight
    553.14
  • Scientific Description
    TAK-220 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1alpha to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC90s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs.
  • SMILES
    O=C(C1CCN(C(C)=O)CC1)N(CCCN2CCC(CC3=CC=C(C(N)=O)C=C3)CC2)C4=CC=C(C)C(Cl)=C4
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200