TAK-220 [333994-00-6]
HY-19974
Overview
- SupplierMedChem Express
- Product NameTAK-220 [333994-00-6]
- Delivery Days Customer10
- CAS Number333994-00-6
- CertificationResearch Use Only
- Estimated Purity99.9%
- Molecular FormulaC31H41ClN4O3
- Molecular Weight553.14
- Scientific DescriptionTAK-220 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1alpha to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC90s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs.
- SMILESO=C(C1CCN(C(C)=O)CC1)N(CCCN2CCC(CC3=CC=C(C(N)=O)C=C3)CC2)C4=CC=C(C)C(Cl)=C4
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200