TAK-960 dihydrochloride
HY-15160B
Overview
- SupplierMedChem Express
- Product NameTAK-960 dihydrochloride
- Delivery Days Customer10
- Estimated Purity99.19%
- Molecular FormulaC27H36Cl2F3N7O3
- Molecular Weight634.52
- Scientific DescriptionTAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 dihydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 dihydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.
- SMILES[H]Cl.O=C(NC1CCN(C)CC1)C2=CC(OC)=C(NC3=NC=C(N4C)C(N(C5CCCC5)CC(F)(F)C4=O)=N3)C=C2F.[H]Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200