Talazoparib [1207456-01-6]

Catalog number: HY-16106_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: 5 mg
10 mM
50 mg
100 mg
200 mg
Price: € 131.00
Expected delivery time: 10 days

Product specifications for - Talazoparib [1207456-01-6]

Product group: Chemicals
Category: Other
CAS No.: 1207456-01-6
Purity: >98%
Molecular Formula: C19H14F2N6O
Molecular weight: 380.35
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: BMN 673 is a novel PARP1/2 inhibitor with IC50 of 0.58 nM(PARP1), does not inhibit PARG and is highly sensitive to PTEN mutation. IC50 Value: 0.58 nM Target: PARP BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.
Safety information: 
PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma', Colicchia V. Oncogene. 2017 Aug 17;36(33):4682-4691. Read more
Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9', Yang CS. Mol Cell. 2017 May 18;66(4):503-516.e5. Read more