Umbralisib [1532533-67-7]

MedChem Express

Umbralisib [1532533-67-7]

10

1532533-67-7

Research Use Only

95.05%

C31H24F3N5O3

571.55

Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kdelta and casein kinase-1-epsilon (CK1epsilon) inhibitor, with EC50 of 22.2 nM and 6.0 microM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach.

O=C1C(C2=CC=CC(F)=C2)=C([C@@H](N3N=C(C4=CC=C(OC(C)C)C(F)=C4)C5=C(N)N=CN=C53)C)OC6=CC=C(F)C=C16

2°C to 8°C,-20°C,-80°C

12352200