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Tivozanib [475108-18-0]

Research Use Only
HY-10977
MedChem Express
CAS Number475108-18-0
Product group Chemicals
Estimated Purity99.37%
Molecular Weight454.86
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Tivozanib [475108-18-0]
  • Delivery Days Customer
    10
  • CAS Number
    475108-18-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.37%
  • Molecular Formula
    C22H19ClN4O5
  • Molecular Weight
    454.86
  • Scientific Description
    Tivozanib (AV-951; KRN951) is a selective and orally active VEGFR tyrosine kinase inhibitor with IC50 of 0.21, 0.16, 0.24 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively. Tivozanib inhibits angiogenesis and vascular permeability in tumor tissues and shows antitumor activity. Tivozanib has the potential for the research of metastatic renal cell carcinoma (RCC) .
  • SMILES
    O=C(NC1=CC=C(C=C1Cl)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC4=NOC(C)=C4
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200