Tofacitinib (CP-690550) [477600-75-2]

Selleck Chemicals

Tofacitinib (CP-690550) [477600-75-2]

9

Research Use Only

Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.

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