Tolcapone [134308-13-7]

MedChem Express

Tolcapone [134308-13-7]

10

134308-13-7

Research Use Only

95%

C14H11NO5

273.24

Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of alpha-syn and Abeta42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.

O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=CC=C(C)C=C2

2°C to 8°C,-20°C,-80°C

12352200