Tonabersat [175013-84-0]

Catalog number: HY-15204_5mg
Brand: MedChem Express
Packing: 5 mg
Other sizes: 10 mM
10 mg
50 mg
Price: € 232.00
Expected delivery time: 10 days
Quantity:

Product specifications for - Tonabersat [175013-84-0]

Overview: 
Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 175013-84-0
Properties: 
Purity: >98%
Molecular Formula: C20H19ClFNO4
Molecular weight: 391.8206
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Tonabersat (SB220453) is a gap-junction modulator. IC50 value: Target: gap-junction Tonabersat is a novel benzopyran compound, which in animal models inhibits neurogenic inflammation, blocks propagation of spreading depression and inhibits trigeminal nerve ganglion stimulation-induced carotid vasodilatation.
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: HY-15204; SB-220453; SB 220453; SB220453
METHODS FOR TREATING BRAIN METASTASIS', Massague, Joan. Patent. US 20170258758 A1. Read more
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.', Chen Q. Nature. 2016 May 18;533(7604):493-8. Read more
Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels', Kim Y. Neurotherapeutics. 2017 Oct;14(4):1148-1165. Read more