Trametinib (DMSO solvate) [1187431-43-1]

MedChem Express

Trametinib (DMSO solvate) [1187431-43-1]

10

1187431-43-1

Research Use Only

98.51%

C28H29FIN5O5S

693.53

Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis.

CN1C(C(C)=C(N(C(N(C2=O)C3CC3)=O)C4=CC=CC(NC(C)=O)=C4)C2=C1NC5=CC=C(C=C5F)I)=O.CS(C)=O

2°C to 8°C,-20°C,-80°C

12352200