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Chemical Structure
Chemical Structure
Chemical Structure

Trolox [53188-07-1]

Research Use Only
AG-CR1-3639
AdipoGen Life Sciences
CAS Number53188-07-1
Product group Chemicals
Estimated Purity>98%
Molecular Weight250.3
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Trolox [53188-07-1]
  • Delivery Days Customer
    10
  • CAS Number
    53188-07-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C14H18O4
  • Molecular Weight
    250.3
  • Scientific Description
    Cell permeable and water soluble derivative of vitamin E. Potent antioxidant. Efficiently prevents formation of different reactive oxygen species, such as singlet oxygen (1O2), superoxide anion (O2-) or hydrogen peroxide (H2O2). Commonly used as a standard or positive control in different antioxidant assays, such as ABTS decolorization and FRAP assays, measuring Trolox equivalent antioxidant capacity (TEAC). TEAC assays are used to measure antioxidant capacity of foods, beverages and supplements. Used in biological or biochemical applications to reduce oxidative stress or damage, such as inhibiting peroxynitrite mediated tyrosine nitration and mitochondrial proton permeability. Cytoprotective with low cytotoxicity for different cell lines. Shown to have anticancer activity and to be effective as adjunctive agent in cancer treatments. Used to reduce fluorophore bleaching as well as the fluorophore blinking during the observation of fluorescent labels. Freezing extender supplement in cryopreservation media to improve the quality of cryopreserved human sperm. - Chemical. CAS: 53188-07-1. Formula: C14H18O4. MW: 250.3. Cell permeable and water soluble derivative of vitamin E. Potent antioxidant. Efficiently prevents formation of different reactive oxygen species, such as singlet oxygen (1O2), superoxide anion (O2-) or hydrogen peroxide (H2O2). Commonly used as a standard or positive control in different antioxidant assays, such as ABTS decolorization and FRAP assays, measuring Trolox equivalent antioxidant capacity (TEAC). TEAC assays are used to measure antioxidant capacity of foods, beverages and supplements. Used in biological or biochemical applications to reduce oxidative stress or damage, such as inhibiting peroxynitrite mediated tyrosine nitration and mitochondrial proton permeability. Cytoprotective with low cytotoxicity for different cell lines. Shown to have anticancer activity and to be effective as adjunctive agent in cancer treatments. Used to reduce fluorophore bleaching as well as the fluorophore blinking during the observation of fluorescent labels. Freezing extender supplement in cryopreservation media to improve the quality of cryopreserved human sperm.
  • SMILES
    CC1=C2C(OC(C)(C(O)=O)CC2)=C(C)C(C)=C1O
  • Storage Instruction
    2°C to 8°C,RT
  • UNSPSC
    12352200

References

  • The cytoprotective effect of Trolox demonstrated with three types of human cells: T.W. Wu, et al.; Biochem. Cell Biol. 68, 1189 (1990)
  • Oxidative stress-induced apoptosis prevented by Trolox: V.J. Forrest, et al.; Free Radic. Biol. Med. 16, 675 (1994)
  • Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes: M.G. Salgo & W.A. Pryor; Arch. Biochem. Biophys. 333, 482 (1996)
  • Antioxidant activity applying an improved ABTS radical cation decolorization assay: R. Re, et al.; Free Radical Biol. Med. 26, 1231 (1999)
  • Comparative study of eight well-known polyphenolic antioxidants: P. Cos, et al.; J. Pharm. Pharmacol. 55, 1291 (2003)
  • Free radical scavenger and antioxidant capacity correlation of alpha-tocopherol and Trolox measured by three in vitro methodologies: I.A. Castro, et al.; Int. J. Food Sci. Nutr. 57, 75 (2006)
  • Nonblinking and long-lasting single-molecule fluorescence imaging: I. Rasnik, et al.; Nat. Methods 3, 891 (2006)
  • Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity: Z. Diaz, et al.; Leukemia 21, 2117 (2007)
  • Taxol induces oxidative neuronal cell death by enhancing the activity of NADPH oxidase in mouse cortical cultures: H.J. Jang, et al.; Neurosci. Lett. 443, 17 (2008)
  • Compounds that confer thermal stress resistance and extended lifespan: M.G. Benedetti, et al.; Exp. Gerontol. 43, 882 (2008)