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ProductsBack/Ulipristal acetate [126784-99-4]
Chemical Structure
Chemical Structure
Chemical Structure

Ulipristal acetate [126784-99-4]

Research Use Only
CDX-U0027
Chemodex
CAS Number126784-99-4
DownloadDatasheet
Product group Chemicals
Estimated Purity>98%
Molecular Weight475.62
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Overview

  • Supplier
    Chemodex
  • Product Name
    Ulipristal acetate [126784-99-4]
  • Delivery Days Customer
    10
  • CAS Number
    126784-99-4
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Excepted quantity,Warning
  • Molecular Formula
    C30H37NO4
  • Molecular Weight
    475.62
  • Scientific Description
    Chemical. CAS: 126784-99-4. Formula: C30H37NO4. MW: 475.62. Synthetic. Ulipristal acetate is a selective progesterone receptor modulator (SPRM) that binds to the human progesterone receptors PR-A and PR-B (EC50s=8.5 and 7.7nM, respectively), rabbit uterine PR (EC50=13.6nM), and rabbit thymic glucocorticoid receptor (GR; EC50=15.4nM). It is selective for human progesterone receptors over the human estrogen receptor (ER; EC50>10,000nM). It inhibits growth of IGROV-1 and SKOV3 human ovarian cancer cells (IC50s=15.5 and 31.5microM, respectively) even after resistance to combined cisplatin and paclitaxel treatment has developed. Ulipristal acetate reverses the proliferative effect of progesterone on patient-derived germline mutant BRCA1 breast tissue xenografts in ovariectomized athymic mice. Formulations containing ulipristal acetate have been used as emergency contraceptives and to treat uterine fibroids. - Ulipristal acetate is a selective progesterone receptor modulator (SPRM) that binds to the human progesterone receptors PR-A and PR-B (EC50s=8.5 and 7.7nM, respectively), rabbit uterine PR (EC50=13.6nM), and rabbit thymic glucocorticoid receptor (GR; EC50=15.4nM). It is selective for human progesterone receptors over the human estrogen receptor (ER; EC50>10,000nM). It inhibits growth of IGROV-1 and SKOV3 human ovarian cancer cells (IC50s=15.5 and 31.5microM, respectively) even after resistance to combined cisplatin and paclitaxel treatment has developed. Ulipristal acetate reverses the proliferative effect of progesterone on patient-derived germline mutant BRCA1 breast tissue xenografts in ovariectomized athymic mice. Formulations containing ulipristal acetate have been used as emergency contraceptives and to treat uterine fibroids.
  • SMILES
    O=C1CCC2=C3[C@@]([C@@](CC[C@]4(OC(C)=O)C(C)=O)([H])[C@]4(C)C[C@]3([H])C5=CC=C(N(C)C)C=C5)([H])CCC2=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200