UNC0224 [1197196-48-7]

MedChem Express

UNC0224 [1197196-48-7]

10

1197196-48-7

Research Use Only

98%

C26H43N7O2

485.67

UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.

CN1CCC(NC2=C3C=C(OC)C(OCCCN(C)C)=CC3=NC(N4CCN(C)CCC4)=N2)CC1

2°C to 8°C,-20°C,-80°C

12352200