UNC2025 [1429881-91-3]

MedChem Express

UNC2025 [1429881-91-3]

10

1429881-91-3

Research Use Only

96.86%

C28H40N6O

476.66

UNC2025 is a potent, ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia.

CN1CCN(CC2=CC=C(C3=CN([C@@H]4CC[C@@H](O)CC4)C5=NC(NCCCC)=NC=C53)C=C2)CC1

2°C to 8°C,-20°C,-80°C

12352200