Veliparib [912444-00-9]

Catalog number: HY-10129_10mM
Brand: MedChem Express
Packing: 10 mM
Other sizes: 5 mg
10 mg
50 mg
100 mg
200 mg
Price: € 95.00
Expected delivery time: 10 days
Quantity:

Product specifications for - Veliparib [912444-00-9]

Overview: 
Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 912444-00-9
Properties: 
Purity: >98%
Molecular Formula: C13H16N4O
Molecular weight: 244.2923
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. IC50 Value: 5.2 nM(Ki for PARP1), 2.9 nM(Ki for PARP2) [1] Target: PARP1, PARP2 in vitro: ABT-888 is a potent inhibitor of both PARP-1 and PARP-2 with K(i)s of 5.2 and 2.9 nmol/L, respectively. The compound has good oral bioavailability and crosses the blood-brain barrier [1]. ABT-888 displayed excellent potency against both the PARP-1 and PARP-2 enzymes with a K(i) of 5 nM and in a C41 whole cell assay with an EC(50) of 2 nM [2]. ABT-888 reduced clonogenic survival in H460 lung cancer cells, and inhibited DNA repair as shown by enhanced expression of DNA strand break marker histone gamma-H2AX. [3]. in vivo: The oral bioavailability of ABT-888 is 56%-92% in mice, Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after oral administration [1]. ABT-888 (25 mg/kg i.p.) could improve tumor growth delay in a NCI-H460 xenograft model with well tolerated. Combination with radiation, ABT-888 decreases the tumor vessel formation [3].
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: HY-10129; ABT-888; ABT 888; ABT888