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Vercirnon [698394-73-9]

Research Use Only
HY-15724
MedChem Express
CAS Number698394-73-9
Product group Chemicals
Estimated Purity98.19%
Molecular Weight444.93
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Vercirnon [698394-73-9]
  • Delivery Days Customer
    10
  • CAS Number
    698394-73-9
  • Certification
    Research Use Only
  • Estimated Purity
    98.19%
  • Molecular Formula
    C22H21ClN2O4S
  • Molecular Weight
    444.93
  • Scientific Description
    Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 microM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively.
  • SMILES
    O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=CC=C(Cl)C=C2C(C3=CC=[N+]([O-])C=C3)=O)=O
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200