Vinpocetine [42971-09-5]

Catalog number: AG-CN2-0454-M020
Brand: AdipoGen Life Sciences
Packing: 20 mg
Other sizes: 100 mg
Price: € 40.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - Vinpocetine [42971-09-5]

Product group: Chemicals
Category: Other
Source: Semi-synthetic from Voacanga africana.
CAS No.: 42971-09-5
Purity: >98% (HPLC)
Molecular Formula: C22H26N2O2
Molecular weight: 350.5
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at +20°C
Scientific information: 
Scientific info: Selective Ca2+-calmodulin dependent cGMP-phosphodiesterase (PDE1) inhibitor. Shows vasorelaxant activity. Neuroprotective agent. Selectively inhibits voltage-sensitive 2+ channels Potent anti-inflammatory agent. Inhibitor of NF-kappaB-dependent inflammatory responses by directly targeting IKK. Shown to inhibit the NLRP3 inflammasome. Antioxidant. Free radical scavenger. Anticancer compound. Anticonvulsant.
Safety information: 
Hazard information: H302, H319, H335
Additional information: 
Synonyms: AG-CN2-0454-M020; AdipoGen Life Sciences; (3alpha, 16alpha)-Eburnamenine-14-carboxylic acid ethyl ester; Ethyl apovincaminate; RGH-4405; TCV 3B; AY 27255
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol. 38, 3331 (1989) Read more
Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine: J.E. Souness, et al.; Br. J. Pharmacol. 98, 725 (1989) Read more
Vinpocetine selectively inhibits neurotransmitter release triggered by sodium channel activation: M. Sitges & V. Nekrassov; Neurochem. Res. 24, 1585 (1999) Read more
In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine: B. Horvath, et al.; Clin. Neuropharmacol. 25, 37 (2002) Read more
Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons: K. Tarnok, et al.; Neurochem. Int. 53, 289 (2008) Read more
Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine - a PDE1 inhibitor: R. Deshmukh, et al.; Eur. J. Pharmacol. 620, 49 (2009) Read more
Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism: K.I. Jeon, et al.; PNAS 107, 9795 (2010) Read more
Vinpocetine as a potent antiinflammatory agent: A.E. Medina, et al.; PNAS 107, 9921 (2010) Read more
Vinpocetine inhibits breast cancer cells growth in vitro and in vivo: E.W. Huang, et al.; Apoptosis 17, 1120 (2012) Read more
Vinpocetine attenuates lipid accumulation and atherosclerosis formation: Y. Cai, et al.; BBRC 434, 439 (2013) Read more