VU 0240551 [893990-34-6]

MedChem Express

VU 0240551 [893990-34-6]

10

893990-34-6

Research Use Only

99.52%

C16H14N4OS2

342.44

VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission.

O=C(CSC1=NN=C(C2=CC=CC=C2)C=C1)NC3=NC(C)=CS3

2°C to 8°C,-20°C,-80°C

12352200