Tezacaftor [1152311-62-0]
HY-15448
CAS Number1152311-62-0
Product group Chemicals
Estimated Purity98.55%
Molecular Weight520.5
Overview
- SupplierMedChem Express
- Product NameTezacaftor [1152311-62-0]
- Delivery Days Customer10
- CAS Number1152311-62-0
- CertificationResearch Use Only
- Estimated Purity98.55%
- Molecular FormulaC26H27F3N2O6
- Molecular Weight520.5
- Scientific DescriptionTezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation.
- SMILESO=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=CC5=C(N(C[C@@H](O)CO)C(C(C)(C)CO)=C5)C=C4F
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200