XL019 [945755-56-6]
HY-13775
Overview
- SupplierMedChem Express
- Product NameXL019 [945755-56-6]
- Delivery Days Customer10
- CAS Number945755-56-6
- CertificationResearch Use Only
- Estimated Purity95%
- Molecular FormulaC25H28N6O2
- Molecular Weight444.53
- Scientific DescriptionXL019 is a potent, orally active, and selective JAK2 inhibitor, with IC50s of 2.2, 134.3, and 214.2 nM for JAK2, JAK1 and JAK3, respectively. XL019 shows 50-fold or greater selectivity for JAK2, versus a panel of over 100 serine/threonine and tyrosine kinases, including other members of the JAK family. XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2.
- SMILESO=C([C@H]1NCCC1)NC2=CC=C(C3=NC(NC4=CC=C(N5CCOCC5)C=C4)=NC=C3)C=C2
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200