YM155 (Sepantronium Bromide) [781661-94-7]
S1130
Product group Chemicals
Overview
- SupplierSelleck Chemicals
- Product NameYM155 (Sepantronium Bromide) [781661-94-7]
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionYM155 (Sepantronium Bromide) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.
- UNSPSC12352200