ACE2 (human) (rec.) (Biotin)

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Product specifications for - ACE2 (human) (rec.) (Biotin)

Overview:
Product group:	Proteins / Signaling Molecule
Category:	Proteins
Species:	Human
Target:	ACE2
Target description:	angiotensin I converting enzyme 2
Conjugation:	Biotin

Properties:
Purity:	>95% (SDS-PAGE)
Molecular weight:	~110kDa (SDS-PAGE); ~240kDa (Dimer, by SEC)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352202
Concentration:	1 mg/ml
Storage instructions:	2-¦C to 8-¦C, -20-¦C

Scientific information:
Scientific info:	Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19. - Recombinant Proteins. Extracellular domain of human ACE2 (aa 18-740) is fused at the C-terminus to a FLAG®-tag. Source: HEK 293 cells. Lyophilized. Contains PBS. Endotoxin levels: <0.01EU/microg purified protein (LAL test).. Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.
Gene ID:	59272
Swiss prot ID:	Q9BYF1

Safety information:
Hazard information:	Non-hazardous

Additional information:
Synonyms:	ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; angiotensin-converting enzyme homolog; metalloprotease MPROT15; peptidyl-dipeptidase A

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Product specifications for - ACE2 (human) (rec.) (Biotin)