Remdesivir [1809249-37-3]

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Remdesivir Chemical Structure

CAS No. : 1809249-37-3...

Product specifications for - Remdesivir [1809249-37-3]

Overview:
Product group:	Corona Related Products
Category:	Other
CAS No.:	1809249-37-3

Properties:
Purity:	>98%
Molecular Formula:	C27H35N6O8P
Molecular weight:	602.58
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	41116133

Scientific information:
Scientific info:	Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.

Safety information:
MSDS:	MSDS

Additional information:
Synonyms:	HY-104077; GS-5734; MedChem Express

Thi nhu thao T, Labroussaa F, Ebert N, et al. Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. Nature. 2020;582(7813):561-565.

Yin W, Mao C, Luan X, et al. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science. 2020;368(6498):1499-1504.

Yuan S, Chan CC, Chik KK, et al. Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19). Viruses. 2020;12(6)

Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30(3):269-271.

Parang K, El-sayed NS, Kazeminy AJ, Tiwari RK. Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs Against Human Coronavirus 229E (HCoV-229E). Molecules. 2020;25(10)

Vanden eynde JJ. COVID-19: A Brief Overview of the Discovery Clinical Trial. Pharmaceuticals (Basel). 2020;13(4)

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Product specifications for - Remdesivir [1809249-37-3]