Suramin . hexasodium salt [129-46-4]

Catalog number: AG-CR1-3575-M050
Brand: AdipoGen Life Sciences
Packing: 50 mg
Price: € 50.00
Expected delivery time: 7 days
Quantity:
Chemical Structure
Chemical Structure...

Product specifications for - Suramin . hexasodium salt [129-46-4]

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 129-46-4
Properties: 
Purity: >98% (Pharmaceutical Grade)
Molecular Formula: C51H34N6O23S6 . 6Na
Molecular weight: 1291.2 . 137.9
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: 2-¦C to 8-¦C
Scientific information: 
Scientific info: Chemical. CAS: 129-46-4. Formula: C51H34N6O23S6 . 6Na. MW: 1291.2 . 137.9. Synthetic. Potent ATPase inhibitor. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity. Anticancer compound. Protein kinase C (PKC) inhibitor. Potent inhibitor of melanoma heparanase and tumor cell metastasis. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF). TGF-beta1 inhibitor. Topoisomerase I and II inhibitor. Interleukin-1 (IL-1) inhibitor. Interleukin-4 (IL-4) inhibitor. G protein inhibitor. P2X and P2Y purinergic receptor antagonist. Antiangiogenic. Potent VEGF inhibitor. Telomerase inhibitor. Shows adjuvant properties. Regulates ryanodine receptor. Direct adenylyl cyclase inhibitor. Protein synthesis inhibitor. SIRT1 (sirtuin 1) and SIRT5 (sirtuin 5) inhibitor. Immunosuppressive. Antifibrotic agent. Antiparasitic. Antiprotozoal. Athelmintic. Cullin-RING E3 ubiquitin ligase inhibitor. - Potent ATPase inhibitor. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity. Anticancer compound. Protein kinase C (PKC) inhibitor. Potent inhibitor of melanoma heparanase and tumor cell metastasis. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF). TGF-beta1 inhibitor. Topoisomerase I and II inhibitor. Interleukin-1 (IL-1) inhibitor. Interleukin-4 (IL-4) inhibitor. G protein inhibitor. P2X and P2Y purinergic receptor antagonist. Antiangiogenic. Potent VEGF inhibitor. Telomerase inhibitor. Shows adjuvant properties. Regulates ryanodine receptor. Direct adenylyl cyclase inhibitor. Protein synthesis inhibitor. SIRT1 (sirtuin 1) and SIRT5 (sirtuin 5) inhibitor. Immunosuppressive. Antifibrotic agent. Antiparasitic. Antiprotozoal. Athelmintic. Cullin-RING E3 ubiquitin ligase inhibitor.
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-CR1-3575-M050; AdipoGen Life Sciences
Suramin: a potent ATPase inhibitor which acts on the inside surface of the sodium pump: P.A. Fortes, et al.; Biochim. Biophys. Acta 318, 262 (1973) Read more
Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses: E. De Clerq; Cancer Lett. 8, 9 (1979) Read more
Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III: H. Mitsuya, et al.; Science 226, 172 (1984) Read more
Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A: C.E. Hensey, et al.; FEBS Lett. 258, 156 (1989) Read more
Suramin: prototype of a new generation of antitumor compounds: R.V. La Rocca, et al.; Cancer Cells 2, 106 (1990) (Review) Read more
Suramin. A potent inhibitor of melanoma heparanase and invasion: M. Nakajima, et al.; J. Biol. Chem. 266, 9661 (1991) Read more
Nature of the interaction of growth factors with suramin: C.R. Middaugh, et al.; Biochemistry 31, 9016 (1992) Read more
The antiproliferative effect of suramin on the cancer cell line SW-13 is mediated by the inhibition of transforming growth factor beta 1 (TGF-beta 1): R. Danesi, et al.; Pharmacol. Res. 25, 17 (1992) Read more
Suramin inhibits DNA damage in human prostate cancer cells treated with topoisomerase inhibitors in vitro: H. Yamazaki, et al.; Prostate 23, 25 (1993) Read more
Suramin blocks the binding of interleukin-1 to its receptor and neutralizes IL-1 biological activities: G. Strassmann, et al.; Int. J. Immunopharmacol. 16, 931 (1994) Read more