Coronavirus 2019-nCoV Antigen Reagents

The ongoing pneumonia outbreak in the city of Wuhan is caused by a newly identified coronavirus 2019-nCoV, named by the World Health Organization on January 12th, 2020.
Sino Biological successfully expressed 2019-nCoV spike proteins to develop therapies or further research the virus. This new virus belongs to the Betacoronavirus Genus, which also includes SARS CoV (2003) and MERS CoV (2012). The sequence reveals that 2019-nCoV is more similar to SARS-CoV (70% similarity) than to MERS-CoV (40%). Same as all other coronaviruses, the genome of 2019-nCOV encodes the spike protein, the envelope protein, the membrane protein, and the nucleocapsid protein.

The spike protein (S-protein)
This protein mediates receptor binding and membrane fusion. Spike protein contains two subunits, S1 and S2. S1 contains a receptor binding domain (RBD), which is responsible for recognizing and binding with the cell surface receptor. S2 subunit is the "stem" of the structure, which contains other basic elements needed for the membrane fusion. The spike protein is the common target for neutralizing antibodies and vaccines. It’s been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. Indeed, the recombinant Spike protein can bind with recombinant ACE2 protein [Xu et al., 2020].
The nucleocapsid Protein (N-protein) is the most abundant protein in coronavirus. The N-protein is a highly immunogenic phosphoprotein, and it is normally very conserved. The N protein of coronavirus is often used as a marker in diagnostic assays.


Sino Biological
Sino Biological Inc. is dedicated to infectious disease research. The company started to develop relevant tools for nCOV research, including cDNA clones, antigens, and antibodies, immediately after the sequence was published. The recombinant antigens they provide include the full length S protein (ECD), the S1 subunit, the S2 subunit, the S1 RBD and the N protein. Sino Biological can also provide CRO service for proteins and antibodies.

If you want to order, please send your request to: orders@bio-connect.nl

Cat. No. DescriptionSKUSizeUOMPrice
 VG40588-UT CoV Nucleocapsid VG40588-UT 1 Unit On request
 VG40589-UT CoV spike VG40589-UT 1 Unit On request
 VG40590-UT CoV spike VG40590-UT 1 Unit On request
 VG40591-UT CoV spike VG40591-UT 1 Unit On request
 VG40592-UT CoV spike VG40592-UT 1  Unit On request
 40592-V05H 2019-nCoV Spike Protein (RBD, Fc Tag) 40592-V05H-100 100 µg On request
 40591-V08H 2019-nCoV Spike Protein S1 (His Tag) 40591-V08H-100 100 µg On request
 40591-V02H 2019-nCoV Spike Protein S1 (Fc Tag) 40591-V02H-100 100 µg On request
 40588-V08B 2019-nCOV Nucleocapsid Protein (His tag) 40588-V08B-100 100 µg On request
 40589-V08B1 2019-nCOV Spike Protein (S1+S2, His tag) 40589-V08B1-100 100 µg On request
 40590-V08B 2019-nCOV Spike Protein (S2 ECD, His tag) 40590-V08B-100 100 µg On request
 40591-V08B1 2019-nCOV Spike Protein (S1 subunit, His tag) 40591-V08B1-100 100 µg On request
 40591-V05H1 2019-nCoV Spike Protein S1 (mFc Tag) 40591-V05H1-100 100 µg On request
 40150-RP01 Human SARS Coronavirus Spike S1 Subunit Protein Antibody
 [Cross-reactivity in ELISA with 2019-nCoV Spike RBD]
  50
 100
 µl
 µl
 On request
 40150-T52 Human SARS Coronavirus Spike Antibody, Antigen Affinity Purified
 [Cross-reactivity in ELISA with 2019-nCoV Spike RBD]
  50
 100
 µl
 µl
 On request


2019-nCoV Spike Protein S1 (His Tag)
2019-nCoV Spike Protein S1 (His Tag)
CoV spike
CoV spike
CoV spike