Ferroptosis

Over recent years, researchers have uncovered a new form of programmed cell death other than apoptosis and necroptosis, which is called ferroptosis. This type of cell death is due to accumulated iron in the cells. Similar to oxytosis, the pathway is triggered in response to glutathione (GSH) depletion, which allows the production of reactive oxygen species (ROS). It results in uncontrolled lipid peroxidation followed by regulated cell death. Lipid peroxidation can be decreased by iron chelators and lipohilic antioxidants. Ferroptosis has been linked to cancer cell death, neurodegenerative disease, neurotoxicity, acute renal failure and tissue damage.

With the development of drugs that induce this pathway, it could be possible to activate ferroptosis in cancer cells for treatment purposes. Inducers of this pathway can separated into two groups; the inhibitors of cysteine import, resulting in depletion of GSH, and covalent inhibitors of glutathione peroxidase 4 (GPX4). These two groups of compounds both result in reduced activity of GPX4, leading to increased levels of ROS followed by cell death.

Li et al. have recently published a review on the past, present and future of ferroptosis.
Read more about this pathway in their article.

Several of our suppliers offer tools to investigate this pathway further:


Cat.No.DescriptionSupplier
24431-Methyl-4-vinylpyridinium triflateBioVision
HY-B0215AcetylcysteineMedChem Express
A16848ACSL4 Rabbit pAbABclonal
HY-A0023AAlogliptin MedChem Express
HY-N0683α-Vitamin EMedChem Express
HY-N2016Arteannuin BMedChem Express
HY-16762ArtefenomelMedChem Express
HY-B0094ArtemisininMedChem Express
HY-N0193ArtesunateMedChem Express
HY-17379Atorvastatin hemicalcium saltMedChem Express
HY-N0196BaicaleinMedChem Express
HY-13324Bardoxolone methylMedChem Express
HY-10257BAY 11-7085MedChem Express
HY-15836BAY 87-2243MedChem Express
HY-19543BrusatolMedChem Express
HY-Y0172Butylated hydroxytoluene MedChem Express
HY-B1066ButylhydroxyanisoleMedChem Express
A11612CBS Rabbit mAbABclonal
HY-15725CDDO-ImMedChem Express
HY-129458CerivastatinMedChem Express
HY-109523Cerivastatin sodiumMedChem Express
HY-N1457ChrysosplenetinMedChem Express
HY-B0450CiclopiroxMedChem Express
B2336Ciclopirox OlamineBioVision
HY-B0450ACiclopirox olamineMedChem Express
HY-112063CIL56MedChem Express
HY-17394CisplatinMedChem Express
HY-N0111Coenzyme Q10MedChem Express
A5713CS Rabbit pAbABclonal
HY-N0005CurcuminMedChem Express
HY-N0005SCurcumin D6MedChem Express
HY-106376D,L-Buthionine-(S,R)-sulfoximineMedChem Express
HY-106376BD,L-Buthionine-(S,R)-sulfoximine hydrochlorideMedChem Express
HY-17359DeferasiroxMedChem Express
HY-16564Deferasirox (Fe3+ chelate)MedChem Express
HY-B0568DeferiproneMedChem Express
HY-B0988Deferoxamine mesylateMedChem Express
HY-100587D-GlutamineMedChem Express
B2673DibromobimaneBioVision
HY-N4106Dihydroartemisinic acidMedChem Express
HY-W020044DL-alpha-TocopherolMedChem Express
HY-B1346DL-GlutamineMedChem Express
HY-12886DocebenoneMedChem Express
HY-18973Dp44mTMedChem Express
HY-N0060B(E)-Ferulic acidMedChem Express
HY-N0001(-)-EpicatechinMedChem Express
HY-13653(-)-Epigallocatechin GallateMedChem Express
HY-15763ErastinMedChem Express
HY-B1009Ethylenediaminetetraacetic acid trisodium saltMedChem Express
HY-N0337EugenolMedChem Express
K504EZCell™ Glutathione Detection Kit (Blue Fluorescence)BioVision
B2355EZSolution™ Liproxstatin-1BioVision
ARG30337Ferroptosis/Oxytosis Antibody PanelArigo Biolaboratories
2230Ferrostatin-1BioVision
HY-100579Ferrostatin-1MedChem Express
B2308FIN56BioVision
HY-103087FIN56MedChem Express
HY-14664AFluvastatin sodiumMedChem Express
HY-N0523Gallic acidMedChem Express
A4499GCLC Rabbit mAbABclonal
6211Glutaredoxin 1 Antibody (Clone 28C3)BioVision
K264Glutathione (GSH/GSSG/Total) Fluorometric Assay KitBioVision
K261Glutathione Colorimetric Assay KitBioVision
B2307Glutathione ethyl esterBioVision
K251Glutathione Fluorometric Assay KitBioVision
6214Glutathione Peroxidase 1 Antibody (Clone 2A10)BioVision
6215Glutathione Peroxidase 3 Antibody (Clone 55A)BioVision
6213Glutathione Peroxidase 4 Antibody (Clone 1H11)BioVision
K762Glutathione Peroxidase Activity Colorimetric Assay KitBioVision
E4623Glutathione Reductase (GR)(Human) ELISA KitBioVision
E4625Glutathione Reductase (GR)(rat) ELISA KitBioVision
K761Glutathione Reductase Activity Colorimetric Assay KitBioVision
E4624Glutathione Reductase, mitochondrial (Mouse) ELISA KitBioVision
K263GST Colorimetric Activity Assay KitBioVision
HY-19424HeminMedChem Express
6352Human Recombinant GSRBioVision
HY-N0303IdebenoneMedChem Express
B2676iFSP1BioVision
HY-136057iFSP1 MedChem Express
HY-114481Imidazole ketone erastinMedChem Express
A19020[KO Validated] CD44 Rabbit mAbABclonal
A5831[KO Validated] HELLS Rabbit pAbABclonal
A16429[KO Validated] SCD Rabbit pAbABclonal
HY-50898LapatinibMedChem Express
HY-50898ALapatinib ditosylateMedChem Express
HY-50898BLapatinib ditosylate monohydrateMedChem Express
B2305L-Buthionine-(S,R)-SulfoximineBioVision
HY-106376AL-Buthionine-(S,R)-sulfoximineMedChem Express
HY-Y0337L-CysteineMedChem Express
HY-N0394L-CystineMedChem Express
HY-14608AL-Glutamic acid monosodium saltMedChem Express
HY-N0390L-GlutamineMedChem Express
HY-D0187L-Glutathione reducedMedChem Express
HY-10284LinagliptinMedChem Express
B2312Liproxstatin-1BioVision
HY-12726Liproxstatin-1MedChem Express
HY-N0504LovastatinMedChem Express
K500Methylglyoxal Assay Kit (Colorimetric)BioVision
B2304ML-162BioVision
B2710ML-210BioVision
HY-100003ML-210MedChem Express
HY-100523ML385MedChem Express
B2672MonobromobimaneBioVision
HY-F0003ANADPH (tetracyclohexanamine)MedChem Express
HY-F0003NADPH tetrasodium saltMedChem Express
HY-15760Necrostatin-1MedChem Express
HY-N0198Nordihydroguaiaretic acidMedChem Express
HY-103157PD146176MedChem Express
K461PicoProbe™ Methylglyoxal Assay Kit (Fluorometric)BioVision
K740PicoProbe™ Reduced Glutathione (GSH) Assay Kit (Fluorometric)BioVision
HY-15484Pifithrin-α hydrobromideMedChem Express
HY-16702APifithrin-β hydrobromideMedChem Express
HY-13956PioglitazoneMedChem Express
HY-13956SPioglitazone D4MedChem Express
HY-14601Pioglitazone hydrochlorideMedChem Express
HY-N2329PiperlongumineMedChem Express
HY-B0165APravastatin sodiumMedChem Express
HY-19980APRIMA-1MedChem Express
HY-19980PRIMA-1MetMedChem Express
HY-N6939Pseudolaric Acid BMedChem Express
K464Reduced Glutathione (GSH) Assay Kit (Colorimetric)BioVision
HY-17386RosiglitazoneMedChem Express
HY-14600Rosiglitazone maleateMedChem Express
HY-13426RoxadustatMedChem Express
B2303RSL3BioVision
HY-100218ARSL3MedChem Express
HY-14608(S)-Glutamic acidMedChem Express
HY-10295SB 202190MedChem Express
6351Schistosoma japonicum Recombinant GSTBioVision
HY-12298SetanaxibMedChem Express
HY-17502SimvastatinMedChem Express
HY-14221SiramesineMedChem Express
HY-14221ASiramesine hydrochlorideMedChem Express
A2413SLC7A11 / xCT Rabbit mAbABclonal
HY-10201SorafenibMedChem Express
HY-10201SSorafenib (D3)MedChem Express
HY-10201S1Sorafenib (D4)MedChem Express
HY-10201ASorafenib TosylateMedChem Express
HY-12041SP600125MedChem Express
HY-14655SulfasalazineMedChem Express
HY-100489TBHQMedChem Express
HY-N0414TrigonellineMedChem Express
HY-50935TroglitazoneMedChem Express
HY-101445TroloxMedChem Express
HY-13419U-73122MedChem Express
HY-112909AUAMC-3203 hydrochlorideMedChem Express
HY-14291VildagliptinMedChem Express
HY-14291AVildagliptin dihydrateMedChem Express
HY-N2065Withaferin AMedChem Express
HY-14164ZileutonMedChem Express