Popular antibodies of 10 µl for only € 10


Bimonthly GeneTex offers new popular and high quality antibody samples (10 µl) for only € 10*. Until the end of April we offer antibodies samples related to Epithelial-Mesenchymal Transition (EMT).

Epithelial-Mesenchymal Transition (EMT)

Epithelial-mesenchymal transition (EMT) occurs when largely adherent and polarized epithelial cells acquire the phenotype of more mobile mesenchymal cells. EMT not only facilitates morphogenesis during embryonic development but also promotes invasion and metastasis in tumors. Pathological EMT is associated with E-cadherin repression, which contributes to tumor progression. Various oncogenic pathways (involving, for example, TGF-beta, Wnt/beta-catenin, integrins, and Notch) induce EMT via cytoskeletal rearrangement and activation of E-cadherin repressors, including SNAI1, SNAI2, SIP1, ZEB1, and TCF3.










E-Cadherin antibody [GT477] (GTX629691)
E-cadherin, a calcium-dependent cell-cell adhesion molecule, is a key component of the adherens junctions that are integral in cell adhesion and in maintaining the epithelial cell phenotype. Tumor progression is often associated with the loss of E-cadherin function and the cellular transition to a more motile and invasive phenotype.

N-Cadherin antibody (GTX127345)
Cells that undergo EMT commonly switch from expressing E-cadherin to N-cadherin. The upregulation of N-cadherin expression promotes cell motility and invasion, which is linked to tumor metastasis.

alpha Smooth Muscle Actin antibody (GTX100034)
Alpha-smooth muscle actin (alpha-SMA) is the actin isoform that is predominately expressed within vascular smooth muscle cells and plays an important role in fibrogenesis. Alpha-SMA is also considered to be a mesenchymal marker during EMT.

Vimentin antibody (GTX100619)
Vimentin is an intermediate filament protein that is characteristically upregulated in cells undergoing EMT. During EMT, cytoskeletal intermediate filaments undergo a significant compositional change from keratin (epithelial cells) to vimentin (mesenchymal cells).

ZEB1 antibody [N2C1], Internal (GTX105278)
ZEB1 is a zinc finger- and homeodomain-containing transcription factor that binds to the E-box of target promoters. Its binding to the CDH1 promoter leads to the gene's repression and promotion of tumor invasion and metastasis by inducing EMT.

Cat. No.DescriptionClonalityReactivityApplication

Epithelial Markers

GTX105624Cytokeratin 18 antibody [N2C2], InternalRb pAbHuWB, ICC/IF, IHC-P
GTX112666Cytokeratin 19 antibody [N2C3]Rb pAbHu,Ms,RatWB, ICC/IF, IHC-P
GTX112975Cytokeratin 8 antibody [N1C1]Rb pAbHu,MsWB, ICC/IF, IHC-P, IP
GTX129931Desmoglein 3 antibodyRb pAbHuWB, IP
GTX629691E-Cadherin antibody [GT477]Ms mAbHu,Ms,RatWB, ICC/IF, IHC-P, FACS, IP
GTX100459MUC1 antibodyRb pAbHuWB, ICC/IF, IHC-P, IP
GTX108592ZO-1 antibodyRb pAbHu,MsWB, IHC-P

Mesenchymal Markers

GTX100034alpha Smooth Muscle Actin antibodyRb pAbHu,Ms,Rat,ZfshWB, ICC/IF, IHC-P, IHC-Fr
GTX112794Fibronectin antibody [N1N2], N-termRb pAbHu,MsWB, ICC/IF, IHC-P, IP, ELISA
GTX130705Integrin alpha 5 antibodyRb pAbHu,Ms,RatWB
GTX128839Integrin beta 1 / CD29 antibodyRb pAbHu,Ms,Rat,DogWB, ICC/IF, IHC-P, IP
GTX100458MMP9 antibody [N2C1], InternalRb pAbHu,Ms,BovWB, ICC/IF, IHC-P
GTX127345N-Cadherin antibodyRb pAbHu,Ms,RatWB, ICC/IF, IHC-P, IHC-Fr
GTX130023TGF beta 1 antibodyRb pAbHu,MsWB
GTX100619Vimentin antibodyRb pAbHu,Ms,RatWB, ICC/IF, IHC-P, IHC-Fr, IP

EMT-inducing Transcription Factors

GTX633010beta Catenin antibody [GT2169]Ms mAbHu,MsWB, ICC/IF, IHC-P
GTX125918SNAI1 antibodyRb pAbHu,Ms,RatWB, ICC/IF, IHC-P, IHC
GTX129237TCF3 antibodyRb pAbHuWB, ICC/IF, IP
GTX127310Twist1/2 antibodyRb pAbHu,Ms,RatWB, IHC-P
GTX105278ZEB1 antibody [N2C1], InternalRb pAbHu,MsWB, ICC/IF, IP, ChIP assay

Bonus 2019

Cat. No.DescriptionClonalityReactivityApplication
GTX631940ARID5A antibody [GT18112]Ms mAbHu,MsWB, IHC-Fr
GTX134542CD11b antibodyRb pAbMsWB
GTX134588CDC42 antibodyRb pAbHu,Ms,RatWB
GTX633917Dicer antibody [GT1176]Ms mAbHuWB, ICC/IF
GTX132495GEF-H1 antibodyRb pAbDmWB
GTX134513GLB1 antibodyRb pAbMs,RatWB
GTX133372GSK3 beta antibodyRb pAbHuWB
GTX634834IKK beta antibody [GT685]Ms mAbHuWB
GTX133781IL17A antibodyRb pAbHu,Ms,RatWB, IHC-P
GTX130278KDM5A / Jarid1A / RBBP2 antibodyRb pAbHuWB
GTX134234MEK1 antibodyRb pAbHu,RatWB
GTX634832MMP2 antibody [GT185]Ms mAbHuWB
GTX134086NMDAR2A antibodyRb pAbMsWB
GTX133368pan Synuclein antibodyRb pAbMs,RatWB, ICC/IF, IHC-P, IHC-Fr
GTX634811Park7 / DJ-1 antibody [GT1412]Ms mAbHuWB
GTX134478PER2 antibodyRb pAbHu,MsWB
GTX129275PERK antibodyRb pAbHuWB
GTX134256PKC eta antibodyRb pAbMsWB
GTX634796PKM antibody [GT1810]Ms mAbHu,Ms,RatWB
GTX634162PYK2 antibody [GT858]Ms mAbHuWB
GTX633922QKI antibody [GT228]Ms mAbHu,Ms,RatWB, IHC-P
GTX134122SLIT1 antibodyRb pAbMsWB
GTX133724SMARCA2 antibodyRb pAbHu,MsWB, ICC/IF, IHC-P
GTX633972Synaptophysin antibody [GT2589]Ms mAbMs,RatWB, ICC/IF, IHC-P
GTX634809Tau antibody [GT287]Ms mAbMs,RatWB, ICC/IF
GTX134087TMEM119 antibodyRb pAbMsIHC-P, IHC-Fr
GTX131510TMEM49 antibodyRb pAbHuWB
GTX134541Tropomyosin 4 antibodyRb pAbHuWB
GTX134445TRP2 antibodyRb pAbHuWB
GTX129468ZIC1 antibodyRb pAbHuWB

*Conditions
  • There is a limit of three different items per customer each month.
  • Offer is valid until the 30th of April 2019.
  • You can order these products through the normal procedure where you can set the price at € 10.
  • Mention 'GTX20' on your order to apply for the discount.