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ProductsBack/Incensol [22419-74-5]
Chemical Structure
Chemical Structure
Chemical Structure

Incensol [22419-74-5]

Research Use Only
AG-CN2-0482
AdipoGen Life Sciences
CAS Number22419-74-5
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Product group Chemicals
Estimated Purity>92% (HPLC)
Molecular Weight306.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Incensol [22419-74-5]
  • Delivery Days Customer
    10
  • CAS Number
    22419-74-5
  • Certification
    Research Use Only
  • Estimated Purity
    >92% (HPLC)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C20H34O2
  • Molecular Weight
    306.5
  • Scientific Description
    Chemical. CAS: 22419-74-5. Formula: C20H34O2. MW: 306.5. Isolated from Boswellia papyrifera. Component of the frankincense essential oil. Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. More powerful TRPV3 agonist than incensol acetate (Prod. No. AG-CN2-0484). Potent inhibitor of STAT3. Showed inhibitory activity on IL-6-induced STAT3 activation. Shown to have COX-1 and COX-2 inhibitory activity and cytotoxic activity against selected cancer cell lines. - Component of the frankincense essential oil. Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. More powerful TRPV3 agonist than incensol acetate (Prod. No. AG-CN2-0484). Potent inhibitor of STAT3. Showed inhibitory activity on IL-6-induced STAT3 activation. Shown to have COX-1 and COX-2 inhibitory activity and cytotoxic activity against selected cancer cell lines.
  • SMILES
    C/C1=C\CC/C(C)=C/C[C@]2(C(C)C)CC[C@@](C)(O2)[C@@H](O)CC1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri: N. Banno, et al.; J. Ethnopharmacol. 107, 249 (2006)
  • Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri: T. Akihisa, et al.; Biol. Pharm. Bull. 29, 1976 (2006)
  • Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity: S.I. Ali, et al.; Nat. Prod. Commun. 8, 1365 (2013)
  • Neuroactive and anti-inflammatory frankincense cembranes: A structure-activity study: F. Pollastro, et al.; J. Nat. Prod. 79, 1762 (2016)