JNJ-61432059 [2035814-50-5]

MedChem Express

JNJ-61432059 [2035814-50-5]

10

2035814-50-5

Research Use Only

99.05%

C25H22FN5O2

443.47

JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) gamma-8, with a pIC50 of 9.7 for GluA1/gamma-8. Exhibits time- and dose-dependent AMPAR/gamma-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.

OC1CCN(C2=NC=CC3=C(C4=CC=C(NC(C5)=O)C5=C4)C(C6=CC=C(F)C=C6)=NN32)CC1

2°C to 8°C,-20°C,-80°C

12352200