Nevanimibe hydrochloride [133825-81-7]

MedChem Express

Nevanimibe hydrochloride [133825-81-7]

10

133825-81-7

98.07%

C27H40ClN3O

458.08

Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer.

O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C.[H]Cl

2°C to 8°C,-20°C,-80°C

12352200