Neurodegenerative Disorders

Despite a diverse array of clinical manifestations and affected genes, many of the common neurodegenerative disorders share a similar molecular mechanism. Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion disease are each characterized by the aggregation of mutated or misfolded proteins into amyloid inclusion bodies. Aggregation results when the accumulation of misfolded proteins exceeds the cell's ability to eliminate them via the ubiquitin-proteasome degradation pathway. Some evidence suggests that these inclusions may represent a cellular defense mechanism intended to sequester toxic oligomers or to induce autophagic elimination of the diseased proteins. Effective future strategies for treatment of these neurodegenerative disorders rely on the understanding of the basic pathways affected in these disorders.


Disease
Type of Aggregation
Subcellular
Affected Protein
Brain Region Affected
Alzheimer's Disease (AD)
Neuritic Plaques
Extracellular
Amyloid beta peptide
Cortex, hippocampus, basal forebrain, brain stem
Neurofibrillary tangles
Intracellular
Hyperphosphorylated Tau
Parkinson's Disease (PD)
Lewy Body
Intracellular (Cytoplasm)
α-Synuclein
Substantia nigra, cortex, locus ceruleus, rephe (dopaminergic neurons)
Huntington's Disease (HD)
Intranuclear inclusions & cytoplasmic aggregates
Intracellular
Huntingtin with polyglutamate expansion
Striatum, basal ganglia, cortex, others
Amyotrophic Lateral Sclerosis (ALS)
Bonina bodies and axonal spheroids
Intracellular (Cytoplasm)
Various ALS genes
Spinal motor neurons and motor cortex
Prion Disease
Amyloid Plaque
Intracellular & Extracellular
Prion protein
Cortex, brain stem, thalamus, cerebellum, other

We offer an excellent catalog of high-quality antibodies to study the processes involved in neurodegenerative disorders, the majority of which are validated for multiple applications. Please view the table below of selected antibodies and consider whether they can help accelerate your research.

Alzheimer's DiseaseParkinson's DiseaseHuntington’s DiseaseAmyotrophic Lateral Sclerosis (ALS)Prion Disease

Cat. No.DescriptionClonalityReactivityApplication

Alzheimer's Disease

GTX111347ADAM10 antibody [N1N2], N-termRb pAbHuWB
GTX104940ADAM10 antibody [N2C1], InternalRb pAbHuIHC-P, WB
GTX101358ADAM17 antibody [C2C3], C-termRb pAbHu, Ms, RatIHC-P, WB
GTX130081ADAM9 antibodyRb pAbHu, MsWB
GTX107718ALS2CR3 antibody [C3], C-termRb pAbHuWB
GTX110271APBB2 antibodyRb pAbHuICC/IF, WB
GTX109699APBB3 antibody [N3C3]Rb pAbHuIHC-P, WB
GTX101456Apolipoprotein E antibodyRb pAbHuICC/IF, IHC-P, WB
GTX60446Apolipoprotein E antibody [1H4]Ms mAbHuELISA, FACS, IHC-P, WB
GTX100053Apolipoprotein E antibody [C2C3], C-termRb pAbHuICC/IF, IHC-P, IP, WB
GTX112677APP antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX101336APP antibody [C2C3], C-termRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX113319BACE1 antibody [N1C1]Rb pAbHu, MsIHC-P, WB
GTX103757BACE1 antibody [N1C2]Rb pAbHu, Ms, RatIHC-P, WB
GTX113951BACE2 antibody [C1C3]Rb pAbHu, RatICC/IF, IHC-P, WB
GTX40068beta Amyloid (1-40) antibody [BDI350]Ms mAbHuELISA, ICC/IF, WB
GTX82974beta Amyloid antibodyMs mAbHu, MsELISA, ICC/IF, IHC-Fr, IHC-P, WB
GTX102350Calpain 1 antibodyRb pAbHuFACS, ICC/IF, IHC-P, WB
GTX102340Calpain 1 antibody [N3C2], InternalRb pAbHu, MsICC/IF, IHC-P, IP, WB
GTX102499Calpain 2 antibody [N2C1], InternalRb pAbHu, MsFACS, ICC/IF, IHC-P, WB
GTX62063Cathepsin D antibody [EPR3057Y]Rb mAbHu, MsFACS, ICC/IF, IHC-P, IP, WB
GTX112847Cathepsin D antibody [N2C2], InternalRb pAbHuWB
GTX103988Cathepsin S antibodyRb pAbHu, RatIHC-P, WB
GTX114350Cathepsin S antibodyRb pAbHuICC/IF, IHC-P, WB
GTX60441CDK5 antibody [4E4]Ms mAbHu, Mk, RatELISA, FACS, ICC/IF, IHC-P, WB
GTX108328CDK5 antibody [C2C3], C-termRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX10570CDK5R1 antibodyRb pAbHu, Ms, Rat, BovWB
GTX100301ERAB antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX48613ERAB antibodyGt pAbHu, Ms, Dog, Rat, ZfshIHC, WB
GTX113454ERAB antibody [N1C3]Rb pAbHuIHC-P, WB
GTX633625IDE antibody [GT286]Ms mAbHu, MsIHC-P, WB
GTX111664IDE antibody [N3C1], InternalRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX129086LRP1 (85kDa subunit) antibodyRb pAbHuWB
GTX111680neprilysin/CD10 antibody [N2C1], InternalRb pAbHu, Ms, RatIHC-P, WB
GTX115930Nicastrin antibodyRb pAbHuICC/IF, WB
GTX85063PEN2 antibodyRb pAbHu, Ms, RatELISA, ICC/IF, IHC-P, WB
GTX116016Presenilin 1 antibody [C1C2], InternalRb pAbHu, MsICC/IF, IHC-P, WB
GTX101028Presenilin 1 antibody [C1C3]Rb pAbHu, Ms, RatIHC-P, WB
GTX55758Presenilin 2 antibodyRb pAbHu, Ms, RatIHC, IHC-P, WB
GTX23611RAGE antibodyRb pAbHu, Ms, RatIHC-Fr, IHC-P, WB
GTX103712Seladin 1 antibody [N1C2]Rb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX62137Tau (phospho Ser198) antibody [EPR2400]Rb mAbHuICC/IF, IHC-P, IP, WB
GTX24864Tau (phospho Ser199/Ser202) antibodyRb pAbHu, Ms, RatWB
GTX24846Tau (phospho Ser214) antibodyRb pAbHuWB
GTX50175Tau (phospho Ser262) antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX86695Tau (phospho Ser396) antibodyRb pAbHu, Ms, RatELISA, WB
GTX24861Tau (phospho Ser409) antibodyRb pAbHu, Ms, RatWB
GTX86147Tau (phospho Ser422) antibodyRb pAbHu, Ms, RatELISA, IHC, IHC-P, WB
GTX24862Tau (phospho Ser422) antibodyRb pAbHu, Ms, RatWB
GTX24841Tau (phospho Thr205) antibodyRb pAbHu, Ms, RatWB
GTX24842Tau (phospho Thr212) antibodyRb pAbHu, Ms, RatWB
GTX100866Tau antibodyRb pAbHu, MsIHC-P, WB
GTX112981Tau antibodyRb pAbHu, RatIHC-Fr, IHC-P, WB
GTX49353Tau antibodyChk pAbHu, RatICC/IF, WB
GTX103453tPA antibodyRb pAbHu, Ms, RatIHC-P, WB
GTX121628TRAK2 antibodyRb pAbHu, MsICC/IF, WB
GTX119423TRAK2 antibody [N1N2], N-termRb pAbHu, Ms, RatWB
GTX100465Urokinase antibodyRb pAbHuIHC-P, WB
GTX111747Urokinase antibodyRb pAbHuIHC-P, WB

Amyotrophic Lateral Sclerosis (ALS)

GTX112141alpha Tubulin 4a antibodyRb pAbHu, Ms, Chk, Dm, RatICC/IF, IHC-P, WB
GTX112653alpha Tubulin 4a antibodyRb pAbHu, MsICC/IF, WB
GTX113098alpha Tubulin 4a antibodyRb pAbHu, MsICC/IF, IHC-P, WB
GTX130329ATXN2 antibodyRb pAbHu, MsIHC-P, WB
GTX130331ATXN2 antibodyRb pAbHu, MsICC/IF, W
GTX119046C21orf2 antibody [N1C2]Rb pAbHuICC/IF, IHC-P, WB
GTX119776C9orf72 antibodyRb pAbHu, MsICC/IF, IHC, IHC-P, WB
GTX632041C9orf72 antibody [GT779]Ms mAbHuICC/IF, IHC-P, IP, WB
GTX110048FIG4 antibodyRb pAbHuICC/IF, IHC-P, WB
GTX101810FUS antibody [C1C3]Rb pAbHu, MsIHC-P, WB
GTX113486Galectin3 antibodyRb pAbHu, RatICC/IF, IHC-P, WB
GTX125897Galectin3 antibodyRb pAbHu, RatELISA, IHC-P, WB
GTX101144HSC70 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX111150HSC70 antibody [C1C3]Rb pAbHu, Ms, PigIHC-P, WB
GTX111069HSC70 antibody [N2C1], InternalRb pAbHu, MsICC/IF, IHC-P, WB
GTX130828Nek1 antibodyRb pAbHu, MsICC/IF, WB
GTX105447Optineurin antibodyRb pAbHuICC/IF, IHC-P, IP, WB
GTX132575Optineurin antibodyRb pAbHuICC/IF, IHC-P, WB
GTX120605SCFD1 antibody [N2C1], InternalRb pAbHuIHC-P, WB
GTX100554SOD1 antibodyRb pAbHu, Ms, RatELISA, ICC/IF, IHC-P, WB
GTX100659SOD1 antibodyRb pAbHu, Ms, RatICC/IF, IHC-Fr, IHC-P, WB
GTX128171SQSTM1 (phospho Ser403) antibodyRb pAbHu, Ms, RatFACS, IHC-P, WB
GTX111393SQSTM1 antibodyRb pAbHuICC/IF, WB
GTX629890SQSTM1 antibody [GT1478]Ms mAbHu, MsFACS, ICC/IF, WB
GTX629888SQSTM1 antibody [GT239]Ms mAbHu, RatICC/IF, WB
GTX100685SQSTM1 antibody [N3C1], InternalRb pAbHu, Ms, Rat, Zfsh, Bov, HoneybeeFACS, ICC/IF, IHC-P, IP, WB
GTX113057TBK1/NAK antibody [N2C1], InternalRb pAbHu, MsICC/IF, IHC-P, WB
GTX30202TBK1/NaK ATPase antibody [464.6 or 6H]Rb pAbHu, Ms, Dog, Dm, Pig, RatFACS, ICC/IF, IHC, WB
GTX100579TDP43 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX114210TDP43 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, IP, WB, ChIP-seq
GTX630196TDP43 antibody [GT225]Ms mAbHu, Ms, RatWB
GTX101089VCP antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, IP, WB
GTX113030VCP antibody [N1N2], N-termRb pAbHu, Ms, Dog, RatICC/IF, IHC-P, IP, WB

Huntington’s Disease

GTX132621BDNF antibodyRb pAbMsIHC-P, WB
GTX112099CA150 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX22731Clathrin heavy chain antibody [X22]Ms mAbHu, Ms, RatBlocking, ELISA, FACS, ICC/IF, IHC, IHC-P, IM, IP, WB
GTX100231DCTN1 antibody [C3], C-termRb pAbHu, RatICC/IF, IHC-P, WB
GTX115435Dynactin 2 antibodyRb pAbHuICC/IF, IHC-P, WB
GTX131449HIP1 antibodyRb pAbHuWB
GTX117072HIP1 Related antibody [N1N2], N-termRb pAbHu, RatICC/IF, IHC-P, WB
GTX106273HIP14L/ZDHHC13 antibody [C3], C-termRb pAbHuICC/IF, WB
GTX114469HIP2 antibodyRb pAbHu, MsICC/IF, WB
GTX114192HIP3/ZDHHC17 antibodyRb pAbHu, MsWB
GTX111125HIPPI antibody [C1C3]Rb pAbHuICC/IF, IHC-P, WB
GTX111124HIPPI antibody [N1C3]Rb pAbHuIHC-P, WB
GTX132433Huntingtin antibodyRb pAbHu, RatCC/IF, IHC-P, WB
GTX115247NPEPPS antibody [N3C2-2], InternalRb pAbHu, MsICC/IF, WB
GTX108567PACSIN1 antibodyRb pAbHu, MsIHC-P, WB
GTX129144REST antibodyRb pAbHuIHC-P, WB
GTX114758SH3GL3 antibodyRb pAbMs, RatIHC-P, WB
GTX129156SIN3A antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, IP, WB, ChIP assay
GTX110593SP1 antibodyRb pAbHu, MsICC/IF, IHC-P, IP, WB, ChIP assay
GTX128826Ubiquitin antibodyRb pAbHuWB

Parkinson's Disease

GTX123973ALDH1A1 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX123426ALDH1A1 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX54991alpha Synuclein (phospho Ser129) antibodyRb pAbHu, MsICC/IF, IHC-P, WB
GTX82738alpha Synuclein (phospho Ser129) antibodyRb pAbRatWB
GTX112799alpha Synuclein antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX21903alpha Synuclein antibody [4D6]Ms mAbHu, Ms, RatELISA, IHC, IHC-Fr, IHC-P, WB
GTX115032Ataxin 3 antibodyRb pAbHu, MsICC/IF, IHC-P, WB
GTX101343Ataxin 3 antibodyRb pAbHuICC/IF, WB
GTX100224ATF2 antibodyRb pAbHuIHC-P
GTX27959Cyclin E antibodyRb pAbHu, Ms, RatIHC-Fr, IP, WB
GTX103045Cyclin E1 antibodyRb pAbHuICC/IF, WB
GTX48724Cyclin E2 antibodyRb pAbHu, MsELISA, IP, WB
GTX30448DOPA Decarboxylase antibodyRb pAbMs, RatICC/IF, IHC, IHC-Fr, WB
GTX101616Dopamine beta hydroxylase antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX108180Dopamine Receptor D1 antibody [N1-2], N-termRb pAbHuWB
GTX110703HTRA2 antibodyRb pAbHuIHC-P, WB
GTX132456HTRA2 antibodyRb pAbHuWB
GTX102055MFN2 antibody [N1N2], N-termRb pAbHu, MsIHC-P, WB
GTX132574Park7 / DJ-1 antibodyRb pAbHu, RatIHC-P, WB
GTX132552Park7 / DJ-1 antibodyRb pAbHu, RatIHC-P, WB
GTX132556Park7 / DJ-1 antibodyRb pAbHuWB
GTX30969Parkin antibodyRb pAbHuIP, WB
GTX109637PGP9.5 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX109646PGP9.5 antibodyRb pAbHu, Ms, RatIHC-P, WB
GTX10410PGP9.5 antibodyGp pAbHu, Ms, Mk, RatICC/IF, IHC, IHC-Fr
GTX107851PINK1 antibody [N3C3]Rb pAbHuICC/IF, WB
GTX88986PINK1 antibody, InternalGt pAbRatWB
GTX118561SEPT5 antibody [N3C3]Rb pAbHu, MsIHC-P, WB
GTX113268SIAH1 antibodyRb pAbHuIHC-P, WB
GTX104715SIAH1 antibody [N1], N-termRb pAbMsICC/IF
GTX109676STUB1 antibody [C1C3]Rb pAbHu, MsICC/IF, IHC-P, WB
GTX122827STUB1 antibody [N1C3]Rb pAbHu, Ms, RatIHC-P, WB
GTX32905SYT11 antibodyRb pAbHuIHC-P, WB
GTX111702Transglutaminase 2 antibody [N3C3]Rb pAbHu, MsICC/IF, IHC-P, WB
GTX10372Tyrosine Hydroxylase antibody [185]Ms mAbHu, Ms, RatICC/IF, IHC-Fr, IHC-P, WB
GTX102424Tyrosine Hydroxylase antibody [N1C1]Rb pAbHu, Ms, RatICC/IF, IHC-Fr, IHC-P, WB, IHC-Wm

Prion Disease

GTX113719Grp58/ERp57 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX100297Grp58/ERp57 antibody [C3], C-termRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX113340Grp78 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX102567Grp78 antibody [C2C3], C-termRb pAbHu, MsWB
GTX102580Grp78 antibody [N2C1], InternalRb pAbHu, Ms, RatICC/IF, IHC-P, IP, WB
GTX103232GRP94 antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, IP, WB
GTX103203GRP94 antibody [N1N3]Rb pAbHu, MsICC/IF, IHC-P, IP, WB
GTX102049Hsp40 antibody [N1C1]Rb pAbHuWB
GTX111045HSP70 1L antibody [N1N3]Rb pAbHu, Ms, RatICC/IF, IHC-P, WB
GTX25439HSP70 antibody [3A3]Ms mAbHu, Mk, Ms, RatICC/IF, IHC, IP, WB
GTX109753Hsp90 alpha antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, IP, WB
GTX101448HSP90 beta antibodyRb pAbHu, Ms, RatICC/IF, IHC-P, IP, WB, ELISA-Ag
GTX103322NRF2 antibody [N2C2], InternalRb pAbHu, Ms, RatICC/IF, IHC-P, IP, WB, ChIP assay
GTX14219Prion protein PrP antibody [7D9]Ms mAbELISA, IHC-P, WBHu, Ms, Cat, Deer, Elk, Hm, Shp, Bov
GTX101063PRP antibodyRb pAbHu, MsIHC-P, WB



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