11 November 2021

AMPK signaling regulates NLRP3 inflammation and pyroptosis

Antibody panels containing key antibodies for detecting inflammasomes or pyroptosis


Zhao et al. reported that the polysaccharide from black chokeberry ameliorates inflammation by inhibiting NLRP3 inflammasome and pyroptosis through AMPK signaling. Arigo is proud that their Pyroptosis Antibody Panel (ARG30330) was used for their research and was published in scientific reports.

Arigo offers a series of antibody panels in which comprise the key antibodies for detecting inflammasomes or pyroptosis. Theses panels are the smart solutions to facilitate the research of pyroptosis and inflammation.

Inflammasome and pyroptosis products

Pyroptosis Antibody Panel (ARG30330)

  • Includes the antibodies against the key proteins Caspase-1, GSDMD, and IL-1 beta.
  • Excellent for detecting both pro- and cleaved forms of the key proteins.
  • Includes the most suitable loading control.
  • Works on human and mouse samples.

NLRP3 Inflammasome Antibody Panel (ARG30331)

  • Includes NLRP3 inflammasome components NLRP3, ASC and Caspase-1 antibodies.
  • Includes the most suitable loading control.
  • Works on human and mouse samples.

NLRC4 Inflammasome Antibody Panel (ARG30332)

  • Includes NLRC4 inflammasome components NLRC4, ASC and Caspase-1 antibodies.
  • Includes the most suitable loading control.
  • Works on human and mouse samples.

GSDME-mediated Pyroptosis Antibody Panel (ARG30343)

  • Includes Caspase-3 antibody and GSDME antibody for detecting both pro- and cleaved forms.
  • Includes HMGB1 antibody for detecting lytic cell death.
  • Works on human, mouse and rat samples.

Inflammasome and pyroptosis minifilm

Reference

  • Zhao Y, Liu X, Zheng Y, Liu W, Ding C. Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota. Sci Rep. 2021;11(1):20558.

AMPK signaling regulates NLRP3 inflammation and pyroptosis

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