Akt phosphorylation Pathway Explorer MiniPack

Catalog number: 15-101
Brand: Merck (Millipore)
Packing: 3 vials
Price: € 279.00
Expected delivery time: 7 days
Quantity:

Product specifications for - Akt phosphorylation Pathway Explorer MiniPack

Overview: 
Product group: Other
Properties: 
  Research Use Only
UNSPSC: 60104000
Scientific information: 
Scientific info: Pathway Explorer Antibody MiniPack:Each Pathway Explorer Antibody Minipack contains three related antibodies as part of a signaling cascade or a combination of total and phosphorylated forms of key signaling targets. Each of the three antibodies are 30% the original pack size. Full size versions of each of the Pathway Explorer antibodies are available for sale individually under the same catalog number with the removal of “SP” off of each one (e.g. 05-591SP can be ordered as 05-591). Anti-Akt/PKB, PH Domain, clone SKB1:Akt (protein kinase B), a serine/threonine kinase, has emerged as a critical enzyme in signal transduction pathways involved in cell proliferation, apoptosis, angiogenesis, and diabetes. In mammals three isoforms of Akt (alpha,beta, gamma or Akt 1, 2, 3) are reported that exhibit a high degree of homology, but differ slightly in the localization of their regulatory phosphorylation sites. Aktalpha is the predominant isoform in most tissues, whereas the highest expression of Aktbeta is observed in the insulin-responsive tissues, and Aktgamma is abundant in brain tissue. Each Akt isoform is composed of three functionally distinct regions: an N-terminal pleckstrin homology (PH) domain that provides a lipid-binding module to direct Akt to PIP3, a central catalytic domain, and a C-terminal hydrophobic motif.Anti-phospho-Akt (Thr308), clone 50-1C-25 or Anti-phospho-Akt1/PKBalpha (Ser473), clone 11E6:Akt/PKB is a Ser/Thr kinase and a major known effecter of the PI3 Kinase pathway. It is involved in multiple signaling pathways that relate to many biological processes including metabolism, apoptosis, cell cycle control, angiogenesis, differentiation, and cell growth and proliferation. In mammals, three isoforms of Akt (Akt1/PKCalpha, Akt2/PKBbeta, and Akt3/PKBgamma) exists. They exhibit a high degree of homology, but differ slightly in the localization of their regulatory phosphorylation sites. Akt1 is the predominant isoform that is in most tissues and is thought to have a dominant role in growth, survival, embryonic development, and adipocyte differentiation. Akt2 is correlated with the regulation of glucose homeostasis and is the predominant isoform expressed in insulin-responsive tissues. Akt3 is abundant in brain tissue. Each Akt isoform is composed of three functionally distinct regions: an N-terminal Pleckstrin Homology (PH) domain that provides a lipid-binding module, a central catalytic domain containing Thr308, and a C-terminal hydrophobic motif containing Ser473. The activation of AKT is dependent on a dual regulatory mechanism that requires both its translocation to the plasma membrane and dual phosphorylation on Thr308 and Ser473 by PDK1 and the TORC2 complex, respectively. See full size versions for corresponding references.
Additional information: 
Synonyms: 15-101; Merck; Millipore