Phosphorylation Explorer Pack Sample Kit

Catalog number: 17-499
Brand: Merck (Millipore)
Packing: 1 kit
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Price: € 409.00
Expected delivery time: 7 days

Product specifications for - Phosphorylation Explorer Pack Sample Kit

Product group: Other
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Host: MO
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  Research Use Only
UNSPSC: 60104000
Form supplied:
Storage instructions: See individual components for storage/handling conditions.
Scientific information: 
Scientific info: 4G10 PlatinumThe development of the anti-phosphotyrosine, clone 4G10 in 1989 was a monumental discovery for researchers. 4G10 was the first and is the best single monoclonal antibody for the detection tyrosine phosphorylation. 4G10 is well known for its sensitivity and its ability to detect multiple tyrosine phosphorylations on numerous substrates. It has been validated by thousands of scientific and medical researchers in virtually every application and tyrosine target over the past 2 decades. To improve on something that hundred have tried and no one has succeeded, we pooled 4G10 with the next most highly regarded anti-phosphotyrosine, clone PY20 to make 4G10 Platinum. PY20 itself is a very poor substitute for 4G10, but its additive effect allow for a greater level of detection on more substrates that even 4G10 alone was not capable of. 4A4The identification of protein phosphorylation as a regulatory mechanism originated from studies by Fischer and Krebs in the mid 1950s that later earned them the 1992 Nobel prize. It is the major mechanism for the regulation of diverse cellular processes including cell division, protein synthesis, transcriptional regulation and neurotransmission. The steady state phosphorylation of any given substrate is governed by the opposing activities of kinases and phosphatases. It is now believed that a third of all eukaryotic cellular proteins are phosphorylated and that the majority of all phosphorylation events occur on serine and threonine residues (greater than 95%).
Clone ID: 4G10
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Synonyms: 17-499; Merck; Millipore