PROTAC

PROTACs or Proteolysis Targeting Chimeric Molecules are heterobifunctional nanomolecules that theoretically target any protein for ubiquitination and degradation. In terms of the structure, PROTACs consist of one moiety which is recognized by the E3 ligase. This moiety is then chemically and covalently linked to a small molecule or a protein that recognizes the target protein. The trimeric complex formation leads to the transfer of ubiquitins to the target protein. By removing target proteins directly rather than merely blocking them, PROTACs can provide multiple advantages over small molecule inhibitors, which can require high systemic exposure to achieve sufficient inhibition, often resulting in toxic side effects and eventual drug resistance. PROTAC molecules possess good tissue distribution and the ability to target intracellular proteins, thus can be directly applied to cells or injected into animals without the use of vectors. Targeted protein degradation using the PROTAC technology is emerging as a novel therapeutic method to address diseases, such as cancer, driven by the aberrant expression of a disease-causing protein. In addition to the use of PROTACs for the treatment of human disease, these molecules provide a chemical genetic approach to “knock down” proteins to study their function. Currently, there are several small molecule inhibitors that have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.

References
  1. Sakamoto KM. Protacs for treatment of cancer. Pediatr Res. 2010;67(5):505-508.
  2. Neklesa TK, Winkler JD, Crews CM. Targeted protein degradation by PROTACs. Pharmacol Ther. 2017;174:138-144.

PROTAC related products

MedChemExpress offers more than 2700+ PROTAC related products.

Cat. No.DescriptionCASMolecular FormulaMolecular Weight
HY-13030(+)-JQ-11268524-70-4C23H25ClN4O2S456.99
HY-101763A(S,R,S)-AHPC hydrochloride1448189-80-7C22H31ClN4O3S467.02
HY-103608(S,R,S)-AHPC-(C3-PEG)2-C6-Cl1835705-61-7C39H61ClN4O6S749.44
HY-114176(S,R,S)-AHPC-C4-NH2 hydrochloride2245697-83-8C27H40ClN5O4S566.16
HY-103605(S,R,S)-AHPC-C6-PEG3-C4-Cl1835705-55-9C38H59ClN4O7S751.42
HY-133487B(S,R,S)-AHPC-C8-NH22341796-79-8C31H47N5O4S585.80
HY-42424A(S,R,S)-AHPC-Me dihydrochlorideC23H34Cl2N4O3S517.51
HY-42424(S,R,S)-AHPC-Me hydrochloride1948273-03-7C23H33ClN4O3S481.05
HY-103600(S,R,S)-AHPC-PEG1-N32101200-09-1C26H35N7O5S557.67
HY-103607(S,R,S)-AHPC-PEG2-C4-Cl1835705-57-1C32H47ClN4O6S651.26
HY-103599(S,R,S)-AHPC-PEG2-N32010159-45-0C28H39N7O6S601.72
HY-103603A(S,R,S)-AHPC-PEG2-NH22010159-60-9C28H41N5O6S575.72
HY-103603(S,R,S)-AHPC-PEG2-NH2 hydrochloride2097973-72-1C28H42ClN5O6S612.18
HY-103598(S,R,S)-AHPC-PEG3-N31797406-80-4C30H43N7O7S645.77
HY-103602A(S,R,S)-AHPC-PEG3-NH22010159-56-3C30H45N5O7S619.77
HY-103602(S,R,S)-AHPC-PEG3-NH2 hydrochloride2097971-11-2C30H46ClN5O7S656.23
HY-103601(S,R,S)-AHPC-PEG4-N31797406-81-5C32H47N7O8S689.82
HY-103604A(S,R,S)-AHPC-PEG4-NH22010159-57-4C32H49N5O8S663.83
HY-103604(S,R,S)-AHPC-PEG4-NH2 hydrochloride2064292-52-8C32H50ClN5O8S700.29
HY-130271(S,R,S)-AHPC-PEG5-COOH2172820-14-1C36H54N4O11S750.90
HY-103606(S,R,S)-AHPC-PEG6-C4-Cl1835705-59-3C40H63ClN4O10S827.47
HY-125845A(S,S,S)-AHPC hydrochloride2115897-23-7C22H31ClN4O3S467.02
HY-W0677053,6,9-Trioxaundecanedioic Acid13887-98-4C8H14O7222.19
HY-W0049453,6-Dioxaoctanedioic acid23243-68-7C6H10O6178.14
HY-1184115-Ethynyl-2'-deoxyuridine61135-33-9C11H12N2O5252.22
HY-779596-Maleimidocapronic acid55750-53-3C10H13NO4211.21
HY-692207-Octynoic acid10297-09-3C8H12O2140.18
HY-114305A18742064292-12-0C58H62Cl3F2N9O7S1173.59
HY-118297Ac4ManNAz361154-30-5C16H22N4O10430.37
HY-128359ACBI12375564-55-7C49H58FN9O7S936.10
HY-W015088Amino-PEG3-C2-Amine929-75-9C8H20N2O3192.26
HY-W008005Amino-PEG4-alcohol86770-74-3C8H19NO4193.24
HY-22335Amino-PEG4-C2-amine68960-97-4C10H24N2O4236.31
HY-133020ARD-266C52H59ClN6O7915.51
HY-100972ARV-7711949837-12-0C49H60ClN9O7S2986.64
HY-16954ARV-8251818885-28-7C46H47ClN8O9S923.43
HY-W016735Azido-PEG3-alcohol86520-52-7C6H13N3O3175.19
HY-22340Azido-PEG4-alcohol86770-67-4C8H17N3O4219.24
HY-130324Azido-PEG7-amine1333154-77-0C16H34N4O7394.46
HY-115568BETd-2462140289-17-2C48H55N11O10946.02
HY-101519BETd-2602093388-62-4C43H46N10O6798.89
HY-111546BI-36632341740-84-7C44H42F3N7O12917.84
HY-124625BI-44641227948-02-8C28H28F3N5O4555.55
HY-140922Biotin-PEG4-alkyne1458576-00-5C21H35N3O6S457.58
HY-140889Biotin-PEG4-NHS ester459426-22-3C25H40N4O10S588.67
HY-128833Bis-NH2-PEG2929-59-9C6H16N2O2148.20
HY-108371Boc-C1-PEG2-C4-Cl1835705-53-7C14H27ClO4294.81
HY-108372Boc-C5-O-C5-O-C6-Cl1835705-52-6C21H41ClO4393.00
HY-W014099Boc-NH-C4-acid27219-07-4C10H19NO4217.26
HY-W008474Boc-NH-PEG2-C2-NH2153086-78-3C11H24N2O4248.32
HY-W017772Boc-NH-PEG3139115-92-7C11H23NO5249.30
HY-111433BRD4 degrader AT12098836-45-2C48H58ClN9O5S3972.68
HY-111556BSJ-03-1232361493-16-3C47H56N10O11937.01
HY-101488CC-8851010100-07-8C22H21ClN4O4440.88
HY-133073CCR7 Ligand 1681514-83-0C22H29N5O5S475.56
HY-130800Cereblon modulator 11860875-51-9C22H18ClF2N3O4461.85
HY-112496Cl-C6-PEG4-O-CH2COOH1799506-30-1C16H31ClO7370.87
HY-125835CP-102366268-80-4C44H49N13O7871.94
HY-101838dBET11799711-21-9C38H37ClN8O7S785.27
HY-123844dBET571883863-52-2C34H31ClN8O5S699.18
HY-112588dBET61950634-92-0C42H45ClN8O7S841.37
HY-131230Desmorpholinyl Quizartinib-PEG2-COOH2292116-14-2C30H33N5O7S607.68
HY-103634dFKBP-11799711-22-0C53H64N6O141009.11
HY-130604DT22162365172-42-3C77H96ClF3N10O10S41542.36
HY-111519dTRIM242170695-14-2C55H68N8O13S21113.30
HY-111606DUPA302941-52-2C11H16N2O9320.25
HY-130979EED226-COOHC17H13N5O3335.32
HY-130499ERRα Ligand-Linker Conjugates 1C24H20F9N3O5601.42
HY-44148FAK ligand-Linker Conjugate 12307461-45-4C25H28F3N5O6S583.58
HY-114421FKBP12 PROTAC dTAG-132064175-41-1C57H68N4O151049.17
HY-W007713Fmoc-8-amino-3,6-dioxaoctanoic acid166108-71-0C21H23NO6385.41
HY-123921Gefitinib-based PROTAC 32230821-27-7C47H57ClFN7O8S934.51
HY-125834GMB-475C43H46F3N7O7S861.93
HY-129937AGNE-987C56H67F2N9O8S21096.31
HY-W006524H2N-PEG2-CH2COOH134978-97-5C6H13NO4163.17
HY-111594Homo-PROTAC cereblon degrader 12244520-98-5C32H32N6O10660.63
HY-W055870Hydroxy-PEG1-(CH2)2-Boc671802-00-9C9H18O4190.24
HY-101291Iberdomide1323403-33-3C25H27N3O5449.50
HY-107443I-BET762 carboxylic acid1300019-38-8C20H17ClN4O3396.83
HY-10997Ibrutinib936563-96-1C25H24N6O2440.50
HY-111518JH-XI-10-02 2209085-22-1C53H69N5O9920.14
HY-130707K-Ras ligand-Linker Conjugate 32378261-87-9C49H65N7O10S944.15
HY-130822K-Ras ligand-Linker Conjugate 42378261-83-5C35H51N7O8697.82
HY-130823K-Ras ligand-Linker Conjugate 52378261-85-7C42H59N7O8789.96
HY-130991K-Ras ligand-Linker Conjugate 62378261-89-1C42H60N8O7788.98
HY-A0003Lenalidomide191732-72-6C13H13N3O3259.26
HY-A0003BLenalidomide hemihydrate847871-99-2C13H14N3O3.5268.27
HY-129608Lenalidomide-acetylene-C5-COOHC21H22N2O5382.41
HY-115446ALenalidomide-C4-NH2 hydrochlorideC17H22ClN3O3351.83
HY-122725Lenalidomide-C5-NH22093388-45-3C18H23N3O3329.39
HY-122725BLenalidomide-C5-NH2 hydrochlorideC18H24ClN3O3365.85
HY-130683Lenalidomide-propargyl-C2-NH2 hydrochlorideC18H20ClN3O3361.82
HY-126534ALSN3106729 hydrochlorideC25H29ClF2N8O531.00
HY-42151Mal-amido-PEG2-C2-acid756525-98-1C14H20N2O7328.32
HY-113697Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD 1037589-69-7C26H32N4O8528.55
HY-114312MD-2242136247-12-4C48H43Cl2FN6O6889.80
HY-112155MS40782229036-62-6C45H52ClN9O8S914.47
HY-122562MT-8022231744-29-7C41H41N9O8787.82
HY-107425MZ 11797406-69-9C49H60ClN9O8S21002.64
HY-112376MZP-542010159-47-2C55H66ClN7O9S1036.67
HY-112377MZP-552010159-48-3C57H70ClN7O10S1080.72
HY-108370N33-TEG-COOH201467-81-4C10H19N3O6277.27
HY-42637N3-PEG3-CH2COOH172531-37-2C8H15N3O5233.22
HY-44432Navitoclax-piperazine2143096-93-7C47H56ClF3N6O5S3973.63
HY-30105N-Boc-piperazine57260-71-6C9H18N2O2186.25
HY-107447N-Deshydroxyethyl Dasatinib910297-51-7C20H22ClN7OS443.95
HY-40171NH2-C2-NH-Boc57260-73-8C7H16N2O2160.21
HY-40178NH2-C4-NH-Boc68076-36-8C9H20N2O2188.27
HY-W067489NH2-PEG1-CH2CH2-Boc1260092-46-3C9H19NO3189.25
HY-W007545NH2-PEG36338-55-2C6H15NO3149.19
HY-42776NH2-PEG3-C2-NH-Boc101187-40-0C13H28N2O5292.37
HY-120918NH2-PEG71425973-14-3C14H31NO7325.40
HY-128837Nutlin carboxylic acid2249750-27-2C32H32Cl2N4O6639.53
HY-112100PAC2158322-33-7C94H107N13O161674.93
HY-23417PEG5-Tos155130-15-7C17H28O8S392.46
HY-122702PEG6-(CH2CO2H)277855-76-6C14H26O10354.35
HY-10984Pomalidomide19171-19-8C13H11N3O4273.24
HY-130737Pomalidomide 4'-alkylC5-acid 2225940-49-6C19H21N3O6387.39
HY-130617Pomalidomide-amido-C1-Br2351106-38-0C15H12BrN3O5394.18
HY-128848Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH2351103-63-2C31H44N4O11648.70
HY-128846APomalidomide-C2-NH2 hydrochloride2305369-00-8C15H17ClN4O4352.77
HY-125843Pomalidomide-PEG1-C2-N32271036-44-1C17H18N6O5386.36
HY-128716APomalidomide-PEG3-C2-NH2 TFA2414913-97-4C23H29F3N4O9562.49
HY-141015Pomalidomide-PEG4-azide2271036-47-4C23H30N6O8518.52
HY-112599Pomalidomide-PEG4-C2-NH22225940-52-1C23H32N4O8492.52
HY-21930Pomalidomide-PEG4-C-COOH2097938-44-6C23H29N3O10507.49
HY-41549Pomalidomide-PEG4-Ph-NH21818885-63-0C27H32N4O8540.57
HY-125876PROTAC Bcl2 degrader-12378801-85-3C45H45BrN6O10S941.84
HY-114229PROTAC BET degrader-3C53H64N12O9S1045.22
HY-107451PROTAC BET-binding moiety 12093387-77-8C25H25N7O4487.51
HY-43723PROTAC BET-binding moiety 2916493-82-8C20H17ClN4O4S444.89
HY-111758PROTAC B-Raf degrader 12364367-27-9C36H37N5O12S763.77
HY-129938PROTAC BRD4 degrader for PAC-1C62H77F2N9O12S41306.58
HY-129939PROTAC BRD4 ligand-12313230-51-0C23H18F2N4O5S500.47
HY-103632PROTAC BRD9 Degrader-12097971-01-0C42H45N7O12S2903.98
HY-103628PROTAC CDK9 Degrader-12118356-96-8C33H35N5O7613.66
HY-128845PROTAC CRBN Degrader-12358775-70-7C53H72N8O13S1061.25
HY-111846PROTAC ERα Degrader-21351169-29-3C42H61N5O8763.96
HY-119932PROTAC FAK degrader 12301916-69-6C47H56F3N9O8S2996.13
HY-135345PROTAC FKBP Degrader-32079056-43-0C68H90N6O17S1295.54
HY-114323PROTAC FLT-3 degrader 12230826-81-8C52H61N9O9S21020.23
HY-129523PROTAC K-Ras Degrader-12378258-52-5C53H62N10O10999.12
HY-125877PROTAC Mcl1 degrader-12163793-38-0C45H45BrN6O8S909.84
HY-128842PROTAC MDM2 Degrader-32249750-23-8C72H78Cl4N8O151437.25
HY-111844PROTAC RAR Degrader-11351169-27-1C51H72N4O11917.14
HY-111866PROTAC RIPK degrader-21801547-16-9C52H65N7O11S31060.31
HY-125878PROTAC SGK3 degrader-12381320-35-8C57H73FN10O11S21157.38
HY-103636PROTAC Sirt2 Degrader-12098487-75-1C40H40N10O8S2852.94
HY-13001Quizartinib950769-58-1C29H32N6O4S560.67
HY-129602SD-36C59H62F2N9O12P1158.15
HY-128756SIAIS1782376047-73-1C50H62ClN11O6S21012.68
HY-114872SLF195513-96-3C30H40N2O6524.65
HY-107452SLF-amido-C2-COOH1092369-24-8C34H44N2O9624.72
HY-111875SNIPER(BRD)-12095244-54-3C53H66ClN9O8S21056.73
HY-W008574TGN-02051987-99-6C8H6N4OS206.22
HY-14658Thalidomide50-35-1C13H10N2O4258.23
HY-41547Thalidomide 4-fluoride835616-60-9C13H9FN2O4276.22
HY-23095Thalidomide-5-OH64567-60-8C13H10N2O5274.23
HY-129704AThalidomide-NH-C6-NH2 TFA2093386-51-5C21H25F3N4O6486.44
HY-130854Thalidomide-NH-C6-NH-Boc2093536-13-9C24H32N4O6472.53
HY-103612Thalidomide-O-amido-C3-COOH2308035-51-8C19H19N3O8417.37
HY-115560AThalidomide-O-amido-C3-NH2 TFA2022182-58-5C20H21F3N4O8502.40
HY-103615Thalidomide-O-amido-C4-N32098488-36-7C19H20N6O6428.40
HY-103613Thalidomide-O-amido-C4-NH2 TFA1799711-25-3C21H23F3N4O8516.42
HY-112618AThalidomide-O-amido-C6-NH2 TFA1950635-14-9C23H27F3N4O8544.48
HY-103614Thalidomide-O-amido-C8-NH2 TFA1950635-16-1C25H31F3N4O8572.53
HY-112600AThalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2C27H35F3N4O11648.58
HY-112617AThalidomide-O-amido-PEG2-C2-NH2 TFA1957235-75-4C23H27F3N4O10576.48
HY-103611Thalidomide-O-amido-PEG3-C2-NH2 TFA1957236-21-3C25H31F3N4O11620.53
HY-103597Thalidomide-O-COOH1061605-21-7C15H12N2O7332.26
HY-126458Thalidomide-O-PEG2-propargyl2098487-52-4C20H20N2O7400.38
HY-123937THAL-SNS-0322139287-33-3C40H52N8O10S2869.02
HY-130162Tos-PEG2-O-Propargyl1119249-30-7C14H18O5S298.35
HY-23408Tos-PEG377544-68-4C13H20O6S304.36
HY-130708UNC6852C43H48N10O6S832.97
HY-128767VH032-PEG3-acetylene2098799-80-3C31H42N4O7S614.75
HY-112495VH032-PEG5-C6-Cl1799506-06-1C38H59ClN4O9S783.41
HY-100947VH-2982097381-85-4C27H33N5O4S523.65
HY-111663VL2851448188-57-5C29H32N4O4S532.65
HY-122826ZXH-3-262243076-67-5C38H37ClN8O7S785.27

More products can be found in our search engine.