Angiotensin (1-7) [51833-78-4]

Catalog number: HY-12403_5mg
Brand: MedChem Express
Packing: 5 mg
Other sizes: 10 mg
10 mM
25 mg
50 mg
Price: € 89.00
Expected delivery time: 10 days

Product specifications for - Angiotensin (1-7) [51833-78-4]

Product group: Proteins / Signaling Molecule
Category: Hormones
CAS No.: 51833-78-4
Purity: >98%
Molecular Formula: C41H62N12O11
Molecular weight: 899.0048
Datasheet: Datasheet
  Research Use Only
UNSPSC: 51180000
Scientific information: 
Scientific info: Angiotensin (1-7) inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 uM. IC50 & Target: IC50: 0.65 uM (ACE)[1] In Vitro: Angiotensin 1-7 (Ang 1-7) acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide (NO). Angiotensin (1-7) augments the vasodilation induced by bradykinin (BK) in a concentration-dependent manner in rings preconstricted with the thromboxane analog U46619. The EC50 of BK (2.45+/-0.51 nM versus 0.37+/-0.08 nM) is shifted leftward by 6.6-fold in the presence of 2 uM concentration of Angiotensin (1-7). The BK-induced relaxation response is augmented by Angiotensin (1-7) (0.1 to 2 uM) in a dose-dependent manner. At a concentration of 2 uM Angiotensin (1-7), relaxation to BK is increased 92% compared to BK alone (41+/-4.4% versus 92+/-2.5%, P[1]. Angiotensin 1-7 (Ang 1-7) abrogates the methylglyoxal-modified albumin (MGA)-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-beta-ERK pathway in NRK-52E cells[2]. In Vivo: A seven fold decrease in the plasma level of Angiotensin 1-7 (Ang 1-7) is demonstrated in dextran sulfate sodium (DSS) treated mice compare to untreated (UT) group at day 7 post colitis induction. On the other hand, a significant increase in Ang 1-7 is observed in colon homogenates of DSS treated mice at day 7 (0.09 ng/mL) compare to UT mice (0.04 ng/mL)[3]. The ovariectomized (OV) female Wistar-rats receive estradiol (500 ug/kg/week) or vehicle for two weeks. The animals are anesthetized, cannulated, and the responses including mean arterial pressure, renal blood flow (RBF), and renal vascular resistance at the constant level of renal perfusion pressure to graded infusion of Angiotensin 1-7 (Ang 1-7) at 0, 100 and 300 ng/kg/min are determined in OV and OV estradiol-treated (OVE) rats, treated with vehicle or MasR antagonist, A779. RBF response to Ang 1-7 infusion increased dose-dependently in vehicle (Pdosedose[4].
Safety information: 
Additional information: 
Synonyms: HY-12403; Angiotensin-(1-7); Ang-(1-7)