Angiotensin II human [4474-91-3]

Catalog number: HY-13948_50mg
Brand: MedChem Express
Packing: 50 mg
Other sizes: 10 mg
10 mM
Price: € 295.20
Expected delivery time: 10 days

Product specifications for - Angiotensin II human [4474-91-3]

Product group: Chemicals
Category: Other
CAS No.: 4474-91-3
Purity: >98%
Molecular Formula: C50H71N13O12
Molecular weight: 1046.18
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. IC50 & Target: Angiotensin receptor (AT receptor)[1] In Vitro: Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function[1]. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2]. At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT1 and AT2). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors[3]. In Vivo: To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[3].
Safety information: 
Temporal expressions of cell cycle regulators mRNA during hypertrophic process of H9c2 rat cardiomyocytes induced by angiotensin Ⅱ', LI Jing-mei. Chinese Pharmacological Bulletin, 2017, 33(1): 63-67. Read more