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APAF1 peptide

Research Use Only
GTX27872
GeneTex
ApplicationsNeutralisation/Blocking
Product group Proteins / Signaling Molecules
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    APAF1 peptide
  • Delivery Days Customer
    10
  • Applications
    Neutralisation/Blocking
  • Certification
    Research Use Only
  • Concentration
    0.20 mg/ml
  • Scientific Description
    Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homolog of the key cell death gene CED 4 in C. elegans was identified recently from human and mouse and designated APAF1 for Apoptosis protease-activating factor 1. APAF1 binds to Cytochrome c (APAF2) and Caspase 9 (APAF3), which leads to Caspase 9 activation. Activated Caspase 9 in turn cleaves and activates Caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. APAF1 can also associate with Caspase 4 and Caspase 8. APAF1 transcript is ubiquitously expressed in human tissues.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352202